Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha

被引：59

作者：

Moshyedi, AK

Josephs, MD

Abdalla, EK

Mackay, SLD

Edwards, CK

Copeland, EM

Moldawer, LL

机构：

[1] Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32610 USA

[2] Amgen Inc, Boulder, CO 80301 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 04期

关键词：

D O I：

10.1128/IAI.66.4.1800-1802.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.

引用

收藏

页码：1800 / 1802

页数：3

相关论文

共 50 条

[41] A COMMON POLYMORPHISM OF TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED FACTOR 6 (TRAF6) IS ASSOCIATED WITH AN INCREASED RISK FOR SPONTANEOUS BACTERIAL PERITONITIS [J].

Mai, M. ;

Stengel, S. ;

Al-Herwi, E. ;

Reuken, P. ;

Stallmach, A. ;

Bruns, T. .

JOURNAL OF HEPATOLOGY, 2015, 62 :S384-S384

[42] Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice [J].

Weihong Pan ;

Abba J. Kastin ;

Tova Rigai ;

Robert McLay ;

Chaim G. Pick .

Experimental Brain Research, 2003, 149 :195-199

[43] Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice [J].

Pan, WH ;

Kastin, AJ ;

Rigai, T ;

McLay, R ;

Pick, CG .

EXPERIMENTAL BRAIN RESEARCH, 2003, 149 (02) :195-199

[44] Tumor necrosis factor drives increased splenic monopoiesis in old mice [J].

Loukov, Dessi ;

Naidoo, Avee ;

Puchta, Alicja ;

Marin, Jorge L. Arredondo ;

Bowdish, Dawn M. E. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2016, 100 (01) :121-129

[45] Expression profiling in lymphotoxin and tumor necrosis factor knockout mice [J].

Shakhov, AN ;

Nedospasov, SA .

JOURNAL OF LEUKOCYTE BIOLOGY, 2001, :23-23

[46] Characterization of the cytokine expression profiles of the aorta and liver of young tumor necrosis factor alpha mutant mice [J].

Yanrong Sun ;

Miao Yin ;

Liang Zhang ;

Jie Pan .

Molecular and Cellular Biochemistry, 2012, 366 :59-67

[47] Characterization of the cytokine expression profiles of the aorta and liver of young tumor necrosis factor alpha mutant mice [J].

Sun, Yanrong ;

Yin, Miao ;

Zhang, Liang ;

Pan, Jie .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2012, 366 (1-2) :59-67

[48] Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis [J].

Muhammed AM Suliman ;

Fawzy MH Khalil ;

Salam SA Alkindi ;

Anil V Pathare ;

Ali AA Almadhani ;

Neveen AAI Soliman .

World Journal of Gastrointestinal Pathophysiology, 2012, (05) :92-98

[49] METABOLIC EFFECTS OF TUMOR-NECROSIS-FACTOR ALPHA IN NMRI MICE [J].

MAHONY, SM ;

TISDALE, MJ .

BRITISH JOURNAL OF CANCER, 1990, 61 (04) :514-519

[50] AUGMENTED PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA IN OBESE MICE [J].

YAMAKAWA, T ;

TANAKA, S ;

YAMAKAWA, Y ;

KIUCHI, Y ;

ISODA, F ;

KAWAMOTO, S ;

OKUDA, K ;

SEKIHARA, H .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1995, 75 (01) :51-56

← 1 2 3 4 5 →