Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha

被引：59

作者：

Moshyedi, AK

Josephs, MD

Abdalla, EK

Mackay, SLD

Edwards, CK

Copeland, EM

Moldawer, LL

机构：

[1] Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32610 USA

[2] Amgen Inc, Boulder, CO 80301 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 04期

关键词：

D O I：

10.1128/IAI.66.4.1800-1802.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.

引用

页码：1800 / 1802

页数：3

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