New bis(pyridyl)methane derivatives from 4-hydroxy-2-pyridones: synthesis and antitumoral activity

被引：50

作者：

Cocco, MT ^{[1
]}

Congiu, C ^{[1
]}

Onnis, V ^{[1
]}

机构：

[1] Univ Cagliari, Dipartimento Tossicol, I-09124 Cagliari, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 01期

关键词：

bis(pyridyl)methanes; antitumoral activity; pyridones;

D O I：

10.1016/S0223-5234(02)00002-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bis(pyridyl)methane derivatives 5-40 were obtained from the reaction of 4-hydroxy-2-pyridones 3 and 4 with aldehydes. Compounds 5-40 were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-5) M level and in some case at 10(-7) M concentrations. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：37 / 47

页数：11

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