New bis(pyridyl)methane derivatives from 4-hydroxy-2-pyridones: synthesis and antitumoral activity

被引:49
作者
Cocco, MT [1 ]
Congiu, C [1 ]
Onnis, V [1 ]
机构
[1] Univ Cagliari, Dipartimento Tossicol, I-09124 Cagliari, Italy
关键词
bis(pyridyl)methanes; antitumoral activity; pyridones;
D O I
10.1016/S0223-5234(02)00002-8
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Bis(pyridyl)methane derivatives 5-40 were obtained from the reaction of 4-hydroxy-2-pyridones 3 and 4 with aldehydes. Compounds 5-40 were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-5) M level and in some case at 10(-7) M concentrations. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:37 / 47
页数:11
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