Copper ion detection with improved sensitivity through catalytic quenching of gold nanocluster fluorescence

In this report, a sensitive fluorescence detection of copper (II) ion was developed. Although itself only a weak quencher toward gold nanocluster fluorescence, this ion functioned as a catalyst that accelerated the oxidation of iodide into iodine by a strong oxidant. The so-produced iodine quenched the nanocluster fluorescence through an efficient etching reaction, which rendered a much improved sensitivity for copper detection. Under the optimal conditions, the extent of quenching was found linear to the amount of copper in the range of 0.8-80 nM, and this strategy was capable of detecting copper ion as low as 0.33 nM. The method was selective and was successfully applied for related measurement in practical samples.