Microwave-Assisted Preparation of Quinolone and Quinoline Derivatives

被引：7

作者：

Albrecht, Markus ^{[1
]}

Osetska, Olga ^{[1
]}

Rantanen, Toni ^{[1
]}

Froehlich, Roland ^{[2
]}

Bolma, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

[2] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

SYNLETT | 2010年 / 07期

关键词：

quinoline; quinolinone; one-pot synthesis; microwave; EFFICIENT SYNTHESIS; POLYSUBSTITUTED QUINOLINES; ACID;

D O I：

10.1055/s-0029-1219565

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinolinone derivatives can be obtained in microwaveassisted syntheses by reaction of aniline derivatives with acetylene dicarboxylic esters, a malonic acid diester or beta-keto ester derivatives. The reaction proceeds under mild conditions in short reaction times. Two of the quinolinones were transformed into the corresponding 4-chloroquinolines either by conventional heating or in a microwave-assisted reaction. Further modifications resulted in the formation of the boron adduct or in an agglomerate. The latter was characterized by X-ray crystal structure analysis.

引用

页码：1081 / 1084

页数：4

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