Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

被引：47

作者：

Bychek, Roman M. ^{[1
]}

Levterov, Vadym V. ^{[1
]}

Sadkova, Iryna V. ^{[1
]}

Tolmachev, Andrey A. ^{[1
,2
]}

Mykhailiuk, Pavel K. ^{[1
,2
]}

机构：

[1] Enamine Ltd, Chervonotkatska 78, UA-02094 Kiev, Ukraine

[2] Taras Shevchenko Natl Univ Kyiv, Dept Chem, Volodymyrska 64, UA-01601 Kiev, Ukraine

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 47期

关键词：

amines; cycloaddition; drug discovery; difluorocyclopropane; fluorine; GEM-DIFLUORINATED CYCLOPROPANES; MEDICINAL CHEMISTRY; F-19; NMR; ESCHERICHIA-COLI; MEMBRANE-PROTEIN; FLUORINE; DIFLUOROCARBENE; PROLINE; PEPTIDE; CONFORMATION;

D O I：

10.1002/chem.201705708

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3/NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.

引用

页码：12291 / 12297

页数：7

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