Hypericin Induced Malformation, Mortality and Hepatotoxicity During Zebrafish Development

被引：0
作者：
Shih, Chao-Ming [1 ,2 ]
Tsai, Jen-Ning [3 ]
Wu, Chih-Hsien [1 ]
Ko, Jiunn-Liang [1 ,4 ]
Hsu, Li-Sung [5 ,6 ,7 ]
机构：
[1] Chung Shan Med Univ, Inst Med, 110,Sec 1,Chien Kuo N Rd, Taichung 40201, Taiwan
[2] Yang Ming Hosp, Chiayi, Taiwan
[3] Chung Shan Med Univ, Dept Med Lab & Biotechnol, Taichung, Taiwan
[4] Chung Shan Med Univ Hosp, Dept Med Oncol & Chest Med, Taichung, Taiwan
[5] Chung Shan Med Univ Hosp, Clin Lab, Taichung 40201, Taiwan
[6] Chung Shan Med Univ, Inst Biochem, 110 Sec 1,Chien Kuo N Rd, Taichung 40201, Taiwan
[7] Chung Shan Med Univ, Inst Microbiol & Immunol, 110 Sec 1,Chien Kuo N Rd, Taichung, Taiwan
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2019年 / 17卷 / 04期
关键词：
Development; Hepatotoxicity; Hypericin; Zebrafish; MEDIATED PHOTODYNAMIC THERAPY; CELLS; CYTOTOXICITY; EXPRESSION;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Hypericin, a major bioactive compound from St. John's-wort, has been shown to exert several pharmacological activities including anti-viral, anti-depressant, and anti-cancer effects. However, the effect of hypericin on embryonic development still remains unclear. In this study, we investigated the toxicity of hypericin during embryonic development by using zebrafish as a model organism. Hypericin caused mortality and malformation in zebrafish in a dose- and time-dependent manner. In addition, hypericin also affected the liver development in zebrafish. On the other hand, no overt alteration in angiogenesis was observed in hypericin-treated zebrafish. In addition, no inhibition of Hep3B cell proliferation was observed using xenotransplantation assay in response to hypericin treatment. In conclusion, our findings suggest that hypericin may exhibit hepatotoxicity and lead to malformation and mortality during embryonic development in zebrafish.
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收藏
页码：432 / 436
页数：5
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