Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

被引：203

作者：

Wang, Rui ^{[1
]}

Li, Xingshu ^{[2
]}

Yoon, Juyoung ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[2] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 17期

基金：

中国国家自然科学基金; 新加坡国家研究基金会;

关键词：

photodynamic therapy; photosensitizer; organelle-targeted; subcellular localization; precision; AGGREGATION-INDUCED EMISSION; CYCLOMETALATED IRIDIUM(III) COMPLEXES; RUTHENIUM(II) POLYPYRIDYL COMPLEXES; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; PLASMA-MEMBRANE; CANCER-THERAPY; DRUG-DELIVERY; SELF-DELIVERY; CELL-DEATH;

D O I：

10.1021/acsami.1c02019

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented.

引用

页码：19543 / 19571

页数：29

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