COVID-19 and Cardiovascular Disease From Bench to Bedside

被引：257
作者：
Chung, Mina K. [1 ,2 ,3 ]
Zidar, David A. [3 ,4 ]
Bristow, Michael R. [5 ]
Cameron, Scott J. [1 ,2 ,3 ]
Chan, Timothy [1 ,2 ,3 ]
Harding, Clifford V., III [3 ]
Kwon, Deborah H. [1 ,2 ,3 ]
Singh, Tamanna [1 ,2 ,3 ]
Tilton, John C. [3 ]
Tsai, Emily J. [6 ]
Tucker, Nathan R. [7 ,8 ]
Barnard, John [1 ,2 ]
Loscalzo, Joseph [9 ]
机构：
[1] Cleveland Clin, Cleveland, OH 44106 USA
[2] Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA
[4] Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH USA
[5] Univ Colorado, Anschutz Med Ctr, Aurora, CO USA
[6] Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA
[7] Masonic Med Res Inst, Utica, NY USA
[8] Broad Inst Harvard & MIT, Cardiovasc Dis Initiat, Boston, MA USA
[9] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
CIRCULATION RESEARCH | 2021年 / 128卷 / 08期
关键词：
angiotensin-converting enzyme 2; COVID-19; inflammation; magnetic resonance imaging; thrombosis; ANGIOTENSIN-CONVERTING ENZYME-2; CARDIAC MAGNETIC-RESONANCE; HUMAN CORONAVIRUS NL63; MYOCARDIAL INJURY; SPIKE PROTEIN; VIRUS ENTRY; HYPERTROPHIC CARDIOMYOPATHY; SARS CORONAVIRUS; PROGNOSTIC VALUE; UP-REGULATION;
D O I：
10.1161/CIRCRESAHA.121.317997
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.
引用
收藏
页码：1214 / 1236
页数：23
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