COVID-19 and Cardiovascular Disease From Bench to Bedside

被引：257
作者：
Chung, Mina K. [1 ,2 ,3 ]
Zidar, David A. [3 ,4 ]
Bristow, Michael R. [5 ]
Cameron, Scott J. [1 ,2 ,3 ]
Chan, Timothy [1 ,2 ,3 ]
Harding, Clifford V., III [3 ]
Kwon, Deborah H. [1 ,2 ,3 ]
Singh, Tamanna [1 ,2 ,3 ]
Tilton, John C. [3 ]
Tsai, Emily J. [6 ]
Tucker, Nathan R. [7 ,8 ]
Barnard, John [1 ,2 ]
Loscalzo, Joseph [9 ]
机构：
[1] Cleveland Clin, Cleveland, OH 44106 USA
[2] Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA
[4] Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH USA
[5] Univ Colorado, Anschutz Med Ctr, Aurora, CO USA
[6] Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA
[7] Masonic Med Res Inst, Utica, NY USA
[8] Broad Inst Harvard & MIT, Cardiovasc Dis Initiat, Boston, MA USA
[9] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
CIRCULATION RESEARCH | 2021年 / 128卷 / 08期
关键词：
angiotensin-converting enzyme 2; COVID-19; inflammation; magnetic resonance imaging; thrombosis; ANGIOTENSIN-CONVERTING ENZYME-2; CARDIAC MAGNETIC-RESONANCE; HUMAN CORONAVIRUS NL63; MYOCARDIAL INJURY; SPIKE PROTEIN; VIRUS ENTRY; HYPERTROPHIC CARDIOMYOPATHY; SARS CORONAVIRUS; PROGNOSTIC VALUE; UP-REGULATION;
D O I：
10.1161/CIRCRESAHA.121.317997
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.
引用
收藏
页码：1214 / 1236
页数：23
相关论文
共 209 条
  • [41] Neuropilin-1 is a host factor for SARS-CoV-2 infection
    Daly, James L.
    Simonetti, Boris
    Klein, Katja
    Chen, Kai-En
    Williamson, Maia Kavanagh
    Anton-Plagaro, Carlos
    Shoemark, Deborah K.
    Simon-Gracia, Lorena
    Bauer, Michael
    Hollandi, Reka
    Greber, Urs F.
    Horvath, Peter
    Sessions, Richard B.
    Helenius, Ari
    Hiscox, Julian A.
    Teesalu, Tambet
    Matthews, David A.
    Davidson, Andrew D.
    Collins, Brett M.
    Cullen, Peter J.
    Yamauchi, Yohei
    [J]. SCIENCE, 2020, 370 (6518) : 861 - +
  • [42] von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke
    Denorme, Frederik
    Vanhooreibeke, Karen
    De Meyer, Simon F.
    [J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [43] Virus entry: Molecular mechanisms and biomedical applications
    Dimitrov, DS
    [J]. NATURE REVIEWS MICROBIOLOGY, 2004, 2 (02) : 109 - 122
  • [44] SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome
    Dolhnikoff, Marisa
    Ferranti, Juliana Ferreira
    de Almeida Monteiro, Renata Aparecida
    Duarte-Neto, Amaro Nunes
    Gomes-Gouvea, Michele Soares
    Degaspare, Natalia Viu
    Delgado, Artur Figueiredo
    Fiorita, Carolina Montanari
    Leal, Gabriela Nunes
    Rodrigues, Regina Maria
    Chaim, Khallil Taverna
    Rebello Pinho, Joao Renato
    Carneiro-Sampaio, Magda
    Mauad, Thais
    Ferraz da Silva, Luiz Fernando
    de Carvalho, Werther Brunow
    Nascimento Saldiva, Paulo Hilario
    Caldini, Elia Garcia
    [J]. LANCET CHILD & ADOLESCENT HEALTH, 2020, 4 (10) : 790 - 794
  • [45] An overview of potential therapeutic agents to treat COVID-19
    Dong, Xueqin
    Tian, Zhenxue
    Shen, Chengwu
    Zhao, Cuirong
    [J]. BIOSCIENCE TRENDS, 2020, 14 (05) : 318 - 327
  • [46] A systematic review of SARS-CoV-2 vaccine candidates
    Dong, Yetian
    Dai, Tong
    Wei, Yujun
    Zhang, Long
    Zheng, Min
    Zhou, Fangfang
    [J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 5 (01)
  • [47] A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    Donoghue, M
    Hsieh, F
    Baronas, E
    Godbout, K
    Gosselin, M
    Stagliano, N
    Donovan, M
    Woolf, B
    Robison, K
    Jeyaseelan, R
    Breitbart, RE
    Acton, S
    [J]. CIRCULATION RESEARCH, 2000, 87 (05) : E1 - E9
  • [48] Tissue-Specific Immunopathology in Fatal COVID-19
    Dorward, David A.
    Russell, Clark D.
    Um, In Hwa
    Elshani, Mustafa
    Armstrong, Stuart D.
    Penrice-Randal, Rebekah
    Millar, Tracey
    Lerpiniere, Chris E. B.
    Tagliavini, Giulia
    Hartley, Catherine S.
    Randle, Nadine P.
    Gachanja, Naomi N.
    Potey, Philippe M. D.
    Dong, Xiaofeng
    Anderson, Alison M.
    Campbell, Victoria L.
    Duguid, Alasdair J.
    Al Qsous, Wael
    BouHaidar, Ralph
    Baillie, J. Kenneth
    Dhaliwal, Kevin
    Wallace, William A.
    Bellamy, Christopher O. C.
    Prost, Sandrine
    Smith, Colin
    Hiscox, Julian A.
    Harrison, David J.
    Lucas, Christopher D.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (02) : 192 - 201
  • [49] Detection of anti-heparin-PF4 complex antibodies in COVID-19 patients on heparin therapy
    Dragonetti, Daniela
    Guarini, Giuseppe
    Pizzuti, Michele
    [J]. BLOOD TRANSFUSION, 2020, 18 (04) : 328 - 328
  • [50] Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic
    Driggin, Elissa
    Madhavan, Mahesh V.
    Bikdeli, Behnood
    Chuich, Taylor
    Laracy, Justin
    Biondi-Zoccai, Giuseppe
    Brown, Tyler S.
    Nigoghossian, Caroline Der
    Zidar, David A.
    Haythe, Jennifer
    Brodie, Daniel
    Beckman, Joshua A.
    Kirtane, Ajay J.
    Stone, Gregg W.
    Krumholz, Harlan M.
    Parikh, Sahil A.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (18) : 2352 - 2371
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