COVID-19 and Cardiovascular Disease From Bench to Bedside

被引：272

作者：

Chung, Mina K. ^{[1
,2
,3
]}

Zidar, David A. ^{[3
,4
]}

Bristow, Michael R. ^{[5
]}

Cameron, Scott J. ^{[1
,2
,3
]}

Chan, Timothy ^{[1
,2
,3
]}

Harding, Clifford V., III ^{[3
]}

Kwon, Deborah H. ^{[1
,2
,3
]}

Singh, Tamanna ^{[1
,2
,3
]}

Tilton, John C. ^{[3
]}

Tsai, Emily J. ^{[6
]}

Tucker, Nathan R. ^{[7
,8
]}

Barnard, John ^{[1
,2
]}

Loscalzo, Joseph ^{[9
]}

机构：

[1] Cleveland Clin, Cleveland, OH 44106 USA

[2] Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA

[4] Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH USA

[5] Univ Colorado, Anschutz Med Ctr, Aurora, CO USA

[6] Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA

[7] Masonic Med Res Inst, Utica, NY USA

[8] Broad Inst Harvard & MIT, Cardiovasc Dis Initiat, Boston, MA USA

[9] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

CIRCULATION RESEARCH | 2021年 / 128卷 / 08期

关键词：

angiotensin-converting enzyme 2; COVID-19; inflammation; magnetic resonance imaging; thrombosis; ANGIOTENSIN-CONVERTING ENZYME-2; CARDIAC MAGNETIC-RESONANCE; HUMAN CORONAVIRUS NL63; MYOCARDIAL INJURY; SPIKE PROTEIN; VIRUS ENTRY; HYPERTROPHIC CARDIOMYOPATHY; SARS CORONAVIRUS; PROGNOSTIC VALUE; UP-REGULATION;

D O I：

10.1161/CIRCRESAHA.121.317997

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.

引用

页码：1214 / 1236

页数：23

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