Effect of atorvastatin withdrawal on circulating coenzyme Q10 concentration in patients with hypercholesterolemia

Statin therapy can reduce the biosynthesis of both cholesterol and coenzyme Q(10) by blocking the common upstream mevalonate pathway. Coenzyme Q(10) depletion has been speculated to play a potential role in statin-related adverse events, and withdrawal of statin is the choice in patients developing myotoxicity or liver toxicity. However, the effect of statin withdrawal on circulating levels of coenzyme Q(10) remains unknown. Twenty-six patients with hypercholesterolemia received atorvastatin at 10 mg/ day for 3 months. Serum lipid profiles and coenzyme Q(10) were assessed before and immediately after 3 months and were also measured 2 and 3 days after the last day on the statin. After 3 months' atorvastatin therapy, serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and coenzyme Q(10) (0.43 +/- 0.23 to 0.16 +/- 0.10 mu g/ mL) were all significantly reduced ( all p < 0.001). On day 2 after the last atorvastatin, the coenzyme Q(10) level was significantly elevated (0.37 +/- 0.16 mu g/mL) and maintained the same levels on day 3 (0.39 +/- 0.18 mu g/mL) compared with those on month 3 (bothp < 0.001), while TC and LDL-C did not significantly change within the same 3 days. These results suggest that statin inhibition of coenzyme Q(10)synthesis is less strict than inhibition of cholesterol biosynthesis.