Tertiary Amine Mediated Tandem Cross-Rauhut-Currier/Acetalization Reactions: Access to Functionalized Spiro-3,4-Dihydropyrans

被引：55

作者：

Yao, Weijun ^{[1
]}

Wu, Yihua ^{[1
]}

Wang, Gang ^{[1
]}

Zhang, Yiping ^{[1
]}

Ma, Cheng ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 51期

基金：

中国国家自然科学基金;

关键词：

cross-coupling; cyclization; Lewis bases; Michael addition; tandem reactions; DIELS-ALDER REACTIONS; BAYLIS-HILLMAN REACTION; ENANTIOSELECTIVE SYNTHESIS; CONJUGATE ADDITIONS; MICHAEL ADDITION; CURRIER REACTION; CATALYSIS; CYCLOISOMERIZATION; ORGANOCATALYSIS; CYCLOADDITION;

D O I：

10.1002/anie.200905091

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Γ-Proton transfer furnished the highly selective title reaction in which cyclic bhaloenals 1 react with b,g-unsaturated aketoesters 2 to generate functionalized spiro-3,4-dihydro-2H-pyrans 3 having an a-quaternary carbon center and an adjacent vinyl halide group in skeleton. DBU=1,8-diazabicyclo[5.4.0]undec-7-eno, Tos=4-toluenesulfonyl. © 2009 Wiley-VCH Verlag GmbH &. Co. KGaA.

引用

页码：9713 / 9716

页数：4

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