Multinuclear Catalyst for Copper-Catalyzed Asymmetric Conjugate Addition of Organozinc Reagents

被引：64
|
作者：
Endo, Kohei [1 ]
Ogawa, Mika [1 ]
Shibata, Takanori [1 ]
机构：
[1] Waseda Univ, Dept Chem & Biochem, Sch Adv Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 13期
关键词：
alkylation; synthetic methods; copper; Michael addition; zinc; MANNICH-TYPE REACTION; BETA-AMINO ALCOHOLS; GRIGNARD-REAGENTS; ET2ZN/LINKED-BINOL COMPLEX; ACYCLIC ENONES; ENANTIOSELECTIVE HYDROGENATION; QUATERNARY CENTERS; MICHAEL REACTION; ALDOL REACTION; LINKED-BINOL;
D O I：
10.1002/anie.200906839
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A whole lot o' metal: An efficient copper-catalyzed asymmetric conjugate addition was achieved using a binol-derived ligand. The catalytic system has a turnover number of 2000, and the excellent cata-lytic performance could be attributed to the generation of a multinuclear complex such as 1. binol = 2, 2'-dihydroxy-l, 1'-binaphthyl. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2410 / 2413
页数：4
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