Multinuclear Catalyst for Copper-Catalyzed Asymmetric Conjugate Addition of Organozinc Reagents

被引：64

作者：

Endo, Kohei ^{[1
]}

Ogawa, Mika ^{[1
]}

Shibata, Takanori ^{[1
]}

机构：

[1] Waseda Univ, Dept Chem & Biochem, Sch Adv Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 13期

关键词：

alkylation; synthetic methods; copper; Michael addition; zinc; MANNICH-TYPE REACTION; BETA-AMINO ALCOHOLS; GRIGNARD-REAGENTS; ET2ZN/LINKED-BINOL COMPLEX; ACYCLIC ENONES; ENANTIOSELECTIVE HYDROGENATION; QUATERNARY CENTERS; MICHAEL REACTION; ALDOL REACTION; LINKED-BINOL;

D O I：

10.1002/anie.200906839

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A whole lot o' metal: An efficient copper-catalyzed asymmetric conjugate addition was achieved using a binol-derived ligand. The catalytic system has a turnover number of 2000, and the excellent cata-lytic performance could be attributed to the generation of a multinuclear complex such as 1. binol = 2, 2'-dihydroxy-l, 1'-binaphthyl. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2410 / 2413

页数：4

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