Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis

被引：21

作者：

Jo, Hyeju ^{[1
,2
]}

Choi, Minho ^{[1
,2
]}

Sim, Jaeuk ^{[1
,2
]}

Viji, Mayavan ^{[1
,2
]}

Li, Siyuan ^{[1
,2
]}

Lee, Young Hee ^{[1
,2
]}

Kim, Youngsoo ^{[1
,2
]}

Seo, Seung-Yong ^{[3
,4
]}

Zhou, Yuanyuan ^{[5
]}

Lee, Kiho ^{[5
]}

Kim, Wun-Jae ^{[6
]}

Hong, Jin Tae ^{[1
,2
]}

Lee, Heesoon ^{[1
,2
]}

Jung, Jae-Kyung ^{[1
,2
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, South Korea

[2] Chungbuk Natl Univ, Med Res Ctr, Cheongju 28160, South Korea

[3] Gachon Univ, Coll Pharm, Incheon 21936, South Korea

[4] Gachon Univ, Gachon Inst Pharmaceut Sci, Incheon 21936, South Korea

[5] Korea Univ, Coll Pharm, Sejong 30019, South Korea

[6] Chungbuk Natl Univ, Coll Med, Cheongju 28644, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 15期

基金：

新加坡国家研究基金会;

关键词：

Caffeic acid; Melanogenesis; alpha-MSH; Caffeamide; Skin whitening; B16; MELANOMA-CELLS; TYROSINASE INHIBITORS; DOWN-REGULATION; SIGNALING PATHWAYS; SKIN PIGMENTATION; AGENTS; MELANOCYTES; DISCOVERY; ESTER;

D O I：

10.1016/j.bmcl.2017.06.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of alpha-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3374 / 3377

页数：4

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