Predictive immunogenetic markers in COVID-19

被引：29

作者：

Leite, Mauro de Meira ^{[1
,2
]}

Gonzalez-Galarza, Faviel F. ^{[3
,4
]}

da Silva, Bruno Conde Costa ^{[1
,2
]}

Middleton, Derek ^{[3
]}

dos Santos, Eduardo Jose Melo ^{[1
,2
]}

机构：

[1] Fed Univ Para, Genet Complex Dis Lab, Belem, Para, Brazil

[2] Programa Posgrad Biol Agentes Infecciosos & Paras, Belem, Para, Brazil

[3] Univ Liverpool, Inst Integrat Biol, Liverpool, Merseyside, England

[4] Autonomous Univ Coahuila, Ctr Biomed Res, Fac Med, Torreon, Mexico

来源：

HUMAN IMMUNOLOGY | 2021年 / 82卷 / 04期

关键词：

HLA-B; KIR; Cytokine polymorphisms; COVID-19;

D O I：

10.1016/j.humimm.2021.01.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunorelevant genes are among the most probable modulators of coronavirus disease 2019 (COVID-19) progression and prognosis. However, in the few months of the pandemic, data generated on host genetics has been scarce. The present study retrieved data sets of HLA-B alleles, KIR genes and functional single nucleotide polymorphisms (SNPs) in cytokines related to COVID-19 cytokine storm from two publicly available databases: Allele Frequency Net Database and Ensembl, and correlated these frequency data with Case Fatality Rate (CFR) and Daily Death Rates (DDR) across countries. Correlations of eight HLA-B alleles and polymorphisms in three cytokine genes (IL6, IL10, and IL12B) were observed and were mainly associated with DDR. Additionally, HLA-B correlations suggest that differences in allele affinities to SARSCoV-2 peptides are also associated with DDR. These results may provide rationale for future host genetic marker surveys on COVID-19. (C) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：247 / 254

页数：8

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