A latent aryl hydrazine 'safety-catch' linker compatible with N-alkylation

被引：29

作者：

Berst, F

Holmes, AB

Ladlow, M

Murray, PJ

机构：

[1] Univ Cambridge, Chem Labs, Glaxo Wellcome Cambridge Chem Lab, Cambridge CB2 1EW, England

[2] Univ Cambridge, Dept Chem, Chem Labs, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 34期

关键词：

solid-phase synthesis; alkylation; hydrazines; cyclisation;

D O I：

10.1016/S0040-4039(00)01108-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation and use of a latent aryl hydrazine 'safety-catch' linker for solid-phase chemistry, which is compatible with N-alkylation, is reported. Its use is exemplified by the preparation of mono-ketopiperazines, whereby release from resin is effected via an intramolecular cyclitive cleavage strategy. (C) 2000 Elsevier Science Ltd, All rights reserved.

引用

收藏

页码：6649 / 6653

页数：5

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