A latent aryl hydrazine 'safety-catch' linker compatible with N-alkylation

被引：29
作者：
Berst, F
Holmes, AB
Ladlow, M
Murray, PJ
机构：
[1] Univ Cambridge, Chem Labs, Glaxo Wellcome Cambridge Chem Lab, Cambridge CB2 1EW, England
[2] Univ Cambridge, Dept Chem, Chem Labs, Cambridge CB2 1EW, England
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 34期
关键词：
solid-phase synthesis; alkylation; hydrazines; cyclisation;
D O I：
10.1016/S0040-4039(00)01108-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation and use of a latent aryl hydrazine 'safety-catch' linker for solid-phase chemistry, which is compatible with N-alkylation, is reported. Its use is exemplified by the preparation of mono-ketopiperazines, whereby release from resin is effected via an intramolecular cyclitive cleavage strategy. (C) 2000 Elsevier Science Ltd, All rights reserved.
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页码：6649 / 6653
页数：5
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