Novel series of 8H-quinazolino[4,3-b]quinazolin-8-ones via two Niementowski condensations

被引：88

作者：

Alexandre, FR

Berecibar, A

Wrigglesworth, R

Besson, T

机构：

[1] Univ La Rochelle, Lab Genie Prot & Cellulaire, EA 3169, Grp Chim Organ,UFR Sci Fondamentales & Sci Ingn, F-17042 La Rochelle 1, France

[2] Pfizer Global Res & Dev, Fresnes Labs, F-94265 Fresnes, France

来源：

TETRAHEDRON | 2003年 / 59卷 / 09期

关键词：

nitrogen heterocycles; fused ring systems; microwave-assisted multi-steps synthesis; cyclisation;

D O I：

10.1016/S0040-4020(03)00053-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient microwave-assisted multi-step synthesis of 8H-quinazolino[4,3-b]quinazolin-8-one was investigated. The synthesis involved two Niementowski condensations from anthranilic acids. Homogeneous or heterogeneous conditions were studied with the aim to develop convenient syntheses of the desired compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1413 / 1419

页数：7

共 39 条

[11]

GAVIT A, 1996, BIOORGAN MED CHEM, V4, P1203

[12] Base-modified nucleosides from carbohydrate derived oxazolidinethiones:: a five-step process [J].

Girniene, J ;

Gueyrard, D ;

Tatibouët, A ;

Sackus, A ;

Rollin, P .

TETRAHEDRON LETTERS, 2001, 42 (16) :2977-2980

[13] A new and rapid access to homochiral 2,3-dihydro-oxazolo[2,3-b]quinazolin-5-ones [J].

Gueyrard, D ;

Leoni, O ;

Palmieri, S ;

Rollin, P .

TETRAHEDRON-ASYMMETRY, 2001, 12 (02) :337-340

[14]

Johne, 1986, ALKALOIDS CHEM PHARM, V29, P99

[15]

Johne S, 1984, Fortschr Chem Org Naturst, V46, P159

[16]

KHALIDAR BM, 2001, ORG PROCESS RES DEV, V5, P452

[17] Acylation of aromatics under microwaves in the presence of graphite. [J].

Laporte, C ;

Baules, P ;

Laporterie, A ;

Desmurs, JR ;

Dubac, J .

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE, 1998, 1 (02) :141-150

[18]

LAPORTE C, 1998, C R ACAD SCI PARI 2C, V1, P455

[19] Microwave-assisted high-speed chemistry: a new technique in drug discovery [J].

Larhed, M ;

Hallberg, A .

DRUG DISCOVERY TODAY, 2001, 6 (08) :406-416

[20] PREPARATION OF 4-MERCAPTO AND 4-AMINO QUINAZOLINES [J].

LEONARD, NJ ;

CURTIN, DY .

JOURNAL OF ORGANIC CHEMISTRY, 1946, 11 (04) :349-352

← 1 2 3 4 →