First Vesicular Self-Assembly of Crotocembraneic Acid, a Nano-Sized Fourteen Membered Macrocyclic Diterpenic Acid

被引：9

作者：

Bag, Braja G. ^{[1
]}

Barai, Abir C. ^{[1
]}

Wijesekera, Kanchana ^{[2
]}

Kittakoop, Prasat ^{[2
,3
,4
]}

机构：

[1] Vidyasagar Univ, Dept Chem & Chem Technol, Midnapore 721102, W Bengal, India

[2] Chulabhorn Royal Acad, Chem Biol Program, Chulabhorn Grad Inst, Bangkok 10210, Thailand

[3] Chulabhorn Res Inst, Bangkok 10210, Thailand

[4] Minist Educ, Ctr Excellence Environm Hlth & Toxicol EHT CHE, Bangkok, Thailand

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 17期

关键词：

Crotocembraneic Acid; Croton oblongifolius; diterpene; self-assembly; vesicles; SOFT-NANOCOMPOSITES; ORGANOGELS; HYDROGELS; ENTRAPMENT; NANOTUBES; RELEASE; GELS; ARCHITECTURES; AMPHIPHILES; GENERATION;

D O I：

10.1002/slct.201700500

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Study of the spontaneous self-assembly of molecules in aqueous binary solvent mixture yielding vesicular self-assemblies has been an area of intense research in recent years because of its tremendous potential application in controlled-release drug delivery systems, medical implants, tissue engineering, etc. Crotocembraneic acid1, a nano-sized 14-membered macrocyclic diterpenic acid, is extractable from the leaves of Croton oblongifolius Roxb. First self-assembly property of the nano-sized macrocyclic diterpenoid 1 in aqueous binary solvent mixtures is reported here. The diterpenoid spontaneously self-assembled in aqueous binary solvent mixtures yielding vesicles of nano- to micro-meter diameters. The vesicular self-assemblies were capable of entrapping various fluorophores including the anticancer drug doxorubicin.

引用

页码：4969 / 4973

页数：5

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