A review of anti-infective and anti-inflammatory chalcones

被引:968
作者
Nowakowska, Zdzislawa [1 ]
机构
[1] Adam Mickiewicz Univ Poznan, Dept Chem, PL-60780 Poznan, Poland
关键词
review; chalcones; antibacterial; antifungal; anti-inflammatory; antileishmanial; antimalarial; antiviral; activity;
D O I
10.1016/j.ejmech.2006.09.019
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Chalcones. considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants, and have also been shown to display a diverse array of pharmacological activities. The purpose of this review is to provide an overview of the pharmacological activity of synthetic and naturally occurring chalcones. This review is complementary to earlier reviews and covers more recent reports of antimicrobial activity of chalcones (antibacterial and antifungal), as well as antileishmanial, antimalarial, antiviral and anti-inflammatory activities of these compounds. (c) 2006 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:125 / 137
页数:13
相关论文
共 94 条
[1]   Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria [J].
Belofsky, G ;
Percivill, D ;
Lewis, K ;
Tegos, GP ;
Ekart, J .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (03) :481-484
[2]   CHEMICAL-CONSTITUENTS OF CROTALARIA-MADURENSIS [J].
BHAKUNI, DS ;
CHATURVEDI, R .
JOURNAL OF NATURAL PRODUCTS, 1984, 47 (04) :585-591
[3]   Synthesis of chalcone analogues with increased antileishmanial activity [J].
Boeck, P ;
Falcao, CAB ;
Leal, PC ;
Yunes, RA ;
Cechinel, V ;
Torres-Santos, EC ;
Rossi-Bergmann, B .
BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (05) :1538-1545
[4]   Antifungal activity and studies on mode of action of novel xanthoxyline-derived chalcones [J].
Boeck, P ;
Leal, PC ;
Yunes, RA ;
Cechinel, V ;
López, S ;
Sortino, M ;
Escalante, A ;
Furlán, RLE ;
Zacchino, S .
ARCHIV DER PHARMAZIE, 2005, 338 (2-3) :87-95
[5]   Pinocembrin chalcone:: An antibacterial compound from Helichrysum trilineatum [J].
Bremner, PD ;
Meyer, JJM .
PLANTA MEDICA, 1998, 64 (08) :777-777
[6]   Antiviral activity of hop constituents against a series of DNA and RNA viruses [J].
Buckwold, VE ;
Wilson, RJH ;
Nalca, A ;
Beer, BB ;
Voss, TG ;
Turpin, JA ;
Buckheit, RW ;
Wei, JY ;
Wenzel-Mathers, M ;
Walton, EM ;
Smith, RJ ;
Pallansch, M ;
Ward, P ;
Wells, J ;
Chuvala, L ;
Sloane, S ;
Paulman, R ;
Russell, J ;
Hartman, T ;
Ptak, R .
ANTIVIRAL RESEARCH, 2004, 61 (01) :57-62
[7]   Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata [J].
Cheenpracha, S ;
Karalai, C ;
Ponglimanont, C ;
Subhadhirasakul, S ;
Tewtrakul, S .
BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (06) :1710-1714
[8]   LICOCHALCONE-A, A NEW ANTIMALARIAL AGENT, INHIBITS IN-VITRO GROWTH OF THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM AND PROTECTS MICE FROM P-YOELII INFECTION [J].
CHEN, M ;
THEANDER, TG ;
CHRISTENSEN, SB ;
HVIID, L ;
ZHAI, L ;
KHARAZMI, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) :1470-1475
[9]   The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo [J].
Chen, M ;
Christensen, SB ;
Zhai, L ;
Rasmussen, MH ;
Theander, TG ;
Frokjaer, S ;
Steffansen, B ;
Davidsen, J ;
Kharazmi, A .
JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (05) :1327-1333
[10]   Inhibition of fumarate reductase in Leishmania major and L-donovani by chalcones [J].
Chen, M ;
Zhai, L ;
Christensen, SB ;
Theander, TG ;
Kharazmi, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (07) :2023-2029