A novel aza-Prins-Friedel-Crafts reaction for the synthesis of 4-arylpiperidines

被引：24

作者：

Yadav, J. S. ^{[1
]}

Reddy, B. V. Subba ^{[1
]}

Ramesh, K. ^{[1
]}

Kumar, G. G. K. S. Narayana ^{[1
]}

Gree, Rene ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

[2] Univ Rennes 1, Lab CPM, CNRS, UMR 6510, F-35042 Rennes, France

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 05期

关键词：

Aza-Prins-Friedel-Crafts reaction; Arenes; Homoallylic amines; 4-Arylpiperidines; NATURAL-PRODUCT SYNTHESIS; RITTER REACTION SEQUENCE; DIASTEREOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; EXPEDITIOUS SYNTHESIS; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; LEUCASCANDROLIDE-A; VERSATILE REAGENT; FORMAL SYNTHESIS;

D O I：

10.1016/j.tetlet.2009.12.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehyde, homoallylic amine and arene undergo smooth cyclization in the presence of BF3 center dot CEt2 to afford 4-arylpiperidines in good yields and with high trans-selectivity. This is the first report on the preparation of 4-arylpiperidines via aza-Prins-Friedel-Crafts reaction. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：818 / 821

页数：4

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