Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode

被引：52

作者：

Li, Jian ^{[1
]}

Zhou, Xuelan ^{[2
]}

Zhang, Yan ^{[3
]}

Zhong, Fanglin ^{[4
,5
]}

Lin, Cheng ^{[6
]}

McCormick, Peter J. ^{[7
]}

Jiang, Feng ^{[1
]}

Luo, Jun ^{[3
]}

Zhou, Huan ^{[8
]}

Wang, Qisheng ^{[8
]}

Fu, Yang ^{[9
]}

Duan, Jingjing ^{[10
]}

Zhang, Jin ^{[2
]}

机构：

[1] Gannan Med Univ, Coll Pharmaceut Sci, Ganzhou 341000, Peoples R China

[2] Nanchang Univ, Sch Basic Med Sci, Nanchang 330031, Jiangxi, Peoples R China

[3] Nanchang Univ, Affiliated Hosp 2, Nanchang 330031, Jiangxi, Peoples R China

[4] Shenzhen Crystalo Biopharmaceut Co Ltd, Shenzhen 518118, Peoples R China

[5] Jiangxi Jmerry Biopharmaceut Co Ltd, Ganzhou 341000, Peoples R China

[6] Gannan Med Univ, Lab Prevent & Treatment Cardiovasc & Cerebrovasc, Minist Educ, Ganzhou 341000, Peoples R China

[7] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

[8] Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China

[9] Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China

[10] Nanchang Univ, Human Aging Res Inst HARI, Sch Life Sci, Nanchang 330031, Jiangxi, Peoples R China

来源：

SCIENCE BULLETIN | 2021年 / 66卷 / 07期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.scib.2020.10.018

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：661 / 663

页数：3

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