Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines

被引：24

作者：

Zeng, Yang ^{[1
]}

Zhang, Chunchun ^{[2
]}

Yin, Changzhen ^{[1
]}

Sun, Maoshen ^{[1
]}

Fu, Haiyan ^{[1
]}

Zheng, Xueli ^{[1
]}

Yuan, Maolin ^{[1
]}

Li, Ruixiang ^{[1
]}

Chen, Hua ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CATALYTIC DIRECT ARYLATION; N-IMINOPYRIDINIUM YLIDES; C3-SELECTIVE ARYLATION; HETEROAROMATIC-COMPOUNDS; HETEROCYCLES; OXIDES; BONDS; ALKENYLATION; HETEROARENES; REAGENTS;

D O I：

10.1021/acs.orglett.7b00498

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed highly selective direct diarylation of pyridines has been developed using a transient activator strategy. Both (MeO)(2)SO2 and Cu2O are required for this transformation. The in situ generated N-methylpyridinium salt can be arylated at both 2- and 6-positions under the cooperative Pd/Cu catalysis. A subsequent N-demethylation then gives the 2,6-diarylpyridines. This protocol provides a novel synthetic route for the symmetric 2,6-diarylpyridines.

引用

页码：1970 / 1973

页数：4

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