One-pot copper-catalyzed synthesis of 2-substituted benzothiazoles from 2-iodoanilines, benzyl chlorides and elemental sulfur

被引：33

作者：

Yang, Zhao ^{[1
]}

Hu, Renhe ^{[1
]}

Li, Xiaotong ^{[1
]}

Wang, Xin ^{[1
]}

Gu, Ren ^{[1
]}

Han, Shiqing ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 24期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

One-pot; Copper-catalyzed; Benzyl chloride; 2 Substituted benzothiazoles; 2-ARYLBENZOTHIAZOLES; BENZOXAZOLE; CYCLIZATION; ANALOGS; ACIDS; MILD;

D O I：

10.1016/j.tetlet.2017.05.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot three-component reaction of 2-iodoanilines, benzyl chlorides and elemental sulfur to form 2-substituted benzothiazoles in satisfactory yields (up to 98%) has been described. The reaction tolerated a wide range of functional groups on the aromatic ring. And heterocycle methylene chlorides substrates were also found to be compatible. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2366 / 2369

页数：4

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