Transcriptional control during T-cell development

被引：28

作者：

Clevers, H

Ferrier, P

机构：

[1] Univ Utrecht Hosp, Dept Immunol, NL-3584 CX Utrecht, Netherlands

[2] CNRS Marseille Luminy, INSERM, Ctr Immunol, F-13288 Marseille 9, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(98)80245-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly through interactions with different partners. The challenge is now to understand how these interactions can account for the co-ordination of complex extracellular signals and gene expression programs, such as those involved in T-cell receptor gene recombination and expression. (C) Current Biology Ltd ISSN 0952-7915.

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页码：166 / 171

页数：6

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