STOXI gene in pre-eclampsia and intrauterine growth restriction

被引：40

作者：

Berends, A. L. ^{[1
]}

Bertoli-Avella, A. M. ^{[2
]}

de Groot, C. J. M. ^{[1
]}

van Duijn, C. M. ^{[3
]}

Oostra, B. A. ^{[2
]}

Steegers, E. A. P. ^{[1
]}

机构：

[1] Univ Med Ctr Rotterdam, Erasmus MC, Dept Obstet & Gynaecol, Div Obstet & Prenatal Med, NL-3000 CA Rotterdam, Netherlands

[2] Univ Med Ctr Rotterdam, Erasmus MC, Dept Clin Genet, NL-3000 CA Rotterdam, Netherlands

[3] Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2007年 / 114卷 / 09期

关键词：

imprinting; IUGR; pre-eclampsia; STOXI;

D O I：

10.1111/j.1471-0528.2007.01414.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The STOXI gene, identified as a candidate gene for pre-eclampsia in Dutch women, is placentally expressed and subject to imprinting with preferential transmission of the maternal allele. In our study, STOXI-Y153H frequencies were similar in 157 women with pre-eclampsia (65%) and in 157 controls (64%) from the general Dutch population. In an isolated Dutch population, a distortion could not be demonstrated in the transmission of STOXI-Y153H variation from heterozygous mothers to offspring in 50 and 56 families with pregnancies complicated by preeclampsia or intrauterine growth restriction, respectively. Our findings do not confirm previous suggestions that STOXI plays a major role in Dutch women with pre-eclampsia.

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收藏

页码：1163 / 1167

页数：5

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