Synthesis of NNN Chiral Ruthenium Complexes and Their Cytotoxicity Studies

被引：22

作者：

Nandi, Pran Gobinda ^{[1
]}

Jadi, Praveen Kumar ^{[2
]}

Das, Kanu ^{[1
]}

Prathapa, Siriyara Jagannatha ^{[3
]}

Mandal, Biman B. ^{[2
,4
]}

Kumar, Akshai ^{[1
,4
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India

[2] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Biomat & Tissue Engn Lab, Gauhati 781039, Assam, India

[3] Bruker India Sci Pvt Ltd, Bengaluru 560092, Karnataka, India

[4] Indian Inst Technol Guwahati, Ctr Nanotechnol, Gauhati 781039, Assam, India

来源：

INORGANIC CHEMISTRY | 2021年 / 60卷 / 10期

关键词：

BIOLOGICAL-ACTIVITY; ANTICANCER ACTIVITY; DNA-BINDING; METALLODRUGS; HYDROLYSIS; APOPTOSIS; EFFICIENT; LIGANDS; IRIDIUM; KP1019;

D O I：

10.1021/acs.inorgchem.1c00698

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and characterization of chiral pincer-ruthenium complexes of the type ((NNN)-N-R2)RuCl2 (PPh3) (R = 3-methylbutyl and 3,3dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotoxic effect of pincer-ruthenium complexes on human dermal fibroblasts and human tongue carcinoma cells assessed using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay displayed an inhibition of normal and cancer cell growth in a dose-dependent manner. Intracellular reactive oxygen species (ROS) level measurement, lactate dehydrogenase assay, DNA fragmentation, and necrosis studies revealed that treatment with pincer-ruthenium complexes induced a redox imbalance in SAS cells by upregulating ROS generation and caused necrotic cell death by disrupting the cellular membrane integrity.

引用

页码：7422 / 7432

页数：11

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