Diffusion tensor MRI of axonal plasticity in the rat hippocampus

被引：63

作者：

Laitinen, Teemu ^{[1
]}

Sierra, Alejandra ^{[1
]}

Pitkanen, Asla ^{[1
,2
]}

Grohn, Olli ^{[1
]}

机构：

[1] Univ Kuopio, AI Virtanen Inst Mol Sci, Dept Neurobiol, FI-70211 Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Neurol, FI-70211 Kuopio, Finland

来源：

NEUROIMAGE | 2010年 / 51卷 / 02期

基金：

芬兰科学院;

关键词：

Dentate gyrus; Diffusion tensor imaging; Fractional anisotropy; Epileptogenesis; Structural plasticity; Rat; WATER DIFFUSION; STATUS EPILEPTICUS; BRAIN; TRACT; ANISOTROPY; EPILEPTOGENESIS; ABNORMALITIES; OPTIMIZATION; REGISTRATION; ASSOCIATION;

D O I：

10.1016/j.neuroimage.2010.02.077

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to explore non-invasive imaging methods to detect post-injury structural axonal plasticity. Brain injury was launched by status epilepticus induced by intraperitoneal injection of either kainic acid or pilocarpine. Several months later, ex vivo diffusion tensor magnetic resonance imaging (DTI) showed increased FA in the dentate gyrus of both kainic acid (p<0.01) and pilocarpine animals (p<0.01). Importantly, FA changes correlated (p<0.01) with histologically verified axonal plasticity of myelinated and non-myelinated neuronal fibers. The changes observed in DTI parameters ex vivo in the septal dentate gyrus were also seen by in vivo DTI. As DTI is completely a non-invasive imaging method, these results may pave the way for non-invasive in vivo imaging of axonal plasticity after brain insults. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：521 / 530

页数：10

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