Mortality patterns in long-term survivors of childhood or adolescent central nervous system tumour in Sweden

被引:4
作者
Huang, Wuqing [1 ]
Sundquist, Jan [1 ,2 ,3 ]
Sundquist, Kristina [1 ,2 ,3 ]
Ji, Jianguang [1 ]
机构
[1] Lund Univ Reg Skane, Skane Univ Hosp, Ctr Primary Hlth Care Res, Jan Waldenstroms Gata 35, S-20502 Malmo, Sweden
[2] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA
[3] Shimane Univ, Ctr Community Based Healthcare Res & Educ CoHRE, Sch Med, Dept Funct Pathol, Matsue, Shimane, Japan
基金
瑞典研究理事会;
关键词
Central nervous system tumour; Long-term survivors; Mortality patterns; 5-YEAR SURVIVORS; ADULT SURVIVORS; CANCER; EXPERIENCE; ENDOCRINE; RISK; GAPS; CARE;
D O I
10.1007/s11060-019-03321-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour. Methods We identified 5-year survivors with childhood or adolescent CNS tumour before age 20 years through the Swedish Cancer Registry. Five controls were randomly matched for each patient to generate the reference group. We retrieved information about death via Cause of Death Register. We calculated the absolute excess risk (AER) of death and the hazard ratio (HR) of death using Cox proportional hazard model. Results Long-term survivors with CNS tumour suffered a significant higher risk of overall mortality (HR 6.56, 95% CI 5.71-7.53; AER 5.89, 95% CI 5.03-6.87). The mortality rate declined with the increasing survival time, but it was still higher even after 30 years of follow-up. Malignant neoplasms contributed mostly to late mortality with an AER of 3.75 (95% CI 2.95-4.75). Female survivors, survivors diagnosed at a younger age and survivors with medulloblastoma were particularly strongly associated with a higher risk of death. Conclusions Long-term survivors of childhood and adolescent CNS tumours are at a higher risk of late mortality, and the risk of death is affected by gender, age at diagnosis and types of CNS tumour.
引用
收藏
页码:541 / 549
页数:9
相关论文
共 20 条
[1]   Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer [J].
Armstrong, Gregory T. ;
Chen, Yan ;
Yasui, Yutaka ;
Leisenring, Wendy ;
Gibson, Todd M. ;
Mertens, Ann C. ;
Stovall, Marilyn ;
Oeffinger, Kevin C. ;
Bhatia, Smita ;
Krull, Kevin R. ;
Nathan, Paul C. ;
Neglia, Joseph P. ;
Green, Daniel M. ;
Hudson, Melissa M. ;
Robison, Leslie L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (09) :833-842
[2]   Late Mortality Among 5-Year Survivors of Childhood Cancer: A Summary From the Childhood Cancer Survivor Study [J].
Armstrong, Gregory T. ;
Liu, Qi ;
Yasui, Yutaka ;
Neglia, Joseph P. ;
Leisenring, Wendy ;
Robison, Leslie L. ;
Mertens, Ann C. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (14) :2328-2338
[3]   Risk of Second Primary Thyroid Cancer after Radiotherapy for a Childhood Cancer in a Large Cohort Study: An Update from the Childhood Cancer Survivor Study [J].
Bhatti, Parveen ;
Veiga, Lene H. S. ;
Ronckers, Cecile M. ;
Sigurdson, Alice J. ;
Stovall, Marilyn ;
Smith, Susan A. ;
Weathers, Rita ;
Leisenring, Wendy ;
Mertens, Ann C. ;
Hammond, Sue ;
Friedman, Debra L. ;
Neglia, Joseph P. ;
Meadows, Anna T. ;
Donaldson, Sarah S. ;
Sklar, Charles A. ;
Robison, Leslie L. ;
Inskip, Peter D. .
RADIATION RESEARCH, 2010, 174 (06) :741-752
[4]   Subsequent mortality experience in five-year survivors of childhood, adolescent and young adult cancer in Scotland: A population based, retrospective cohort study [J].
Brewster, David H. ;
Clark, David ;
Hopkins, Leanne ;
Bauer, Jacqui ;
Wild, Sarah H. ;
Edgar, Angela B. ;
Wallace, W. Hamish .
EUROPEAN JOURNAL OF CANCER, 2013, 49 (15) :3274-3283
[5]   Long-term cause-specific mortality among five-year survivors of childhood cancer [J].
Cardous-Ubbink, MC ;
Heinen, RC ;
Langeveld, NE ;
Bakker, PJM ;
Voûte, PA ;
Caron, HN ;
van Leeuwen, FE .
PEDIATRIC BLOOD & CANCER, 2004, 42 (07) :563-573
[6]  
Danckert B.FJ., 2019, NORDCAN CANC INCIDEN
[7]   Long term cause specific mortality among 34489 five year survivors of childhood cancer in Great Britain: population based cohort study [J].
Fidler, Miranda M. ;
Reulen, Raoul C. ;
Winter, David L. ;
Kelly, Julie ;
Jenkinson, Helen C. ;
Skinner, Rod ;
Frobisher, Clare ;
Hawkins, Michael M. .
BMJ-BRITISH MEDICAL JOURNAL, 2016, 354 :i4351
[8]   Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades-Experience from the Nordic countries [J].
Garwicz, Stanislaw ;
Anderson, Harald ;
Olsen, Jorgen H. ;
Winther, Jeanette Falck ;
Sankila, Risto ;
Langmark, Froydis ;
Tryggvadottir, Laufey ;
Moller, Torgil R. .
INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (07) :1659-1666
[9]   Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors - Childhood Cancer Survivor Study [J].
Gurney, JG ;
Kadan-Lottick, NS ;
Packer, RJ ;
Neglia, JP ;
Sklar, CA ;
Punyko, JA ;
Stovall, M ;
Yasui, Y ;
Nicholson, HS ;
Wolden, S ;
McNeil, DE ;
Mertens, AC ;
Robison, LL .
CANCER, 2003, 97 (03) :663-673
[10]   Comparability of cancer identification among Death Registry, Cancer Registry and Hospital Discharge Registry [J].
Ji, Jianguang ;
Sundquist, Kristina ;
Sundquist, Jan ;
Hemminki, Kari .
INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (09) :2085-2093