Recent developments in the CCP-EM software suite

被引：244

作者：

Burnley, Tom ^{[1
]}

Palmer, Colin M. ^{[1
]}

Winn, Martyn ^{[1
]}

机构：

[1] Sci & Technol Facil Council, Sci Comp Dept, Res Complex Harwell, Didcot OX11 0FA, Oxon, England

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2017年 / 73卷

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Collaborative Computational Project for Electron cryo-Microscopy; CCP-EM; cryo-EM; CRYO-EM; ELECTRON CRYOMICROSCOPY; PROTEIN STRUCTURES; RIGID BODIES; REFINEMENT; TOOLS; PREDICTION; MODELS; SYSTEM;

D O I：

10.1107/S2059798317007859

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of its remit to provide computational support to the cryo-EM community, the Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced a software framework which enables easy access to a range of programs and utilities. The resulting software suite incorporates contributions from different collaborators by encapsulating them in Python task wrappers, which are then made accessible via a user-friendly graphical user interface as well as a command-line interface suitable for scripting. The framework includes tools for project and data management. An overview of the design of the framework is given, together with a survey of the functionality at different levels. The current CCP-EM suite has particular strength in the building and refinement of atomic models into cryo-EM reconstructions, which is described in detail.

引用

页码：469 / 477

页数：9

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