Targeted Magnetic Nanotheranostics of Cancer

被引：37

作者：

Belyanina, Irina ^{[1
]}

Kolovskaya, Olga ^{[1
,2
]}

Zamay, Sergey ^{[2
]}

Gargaun, Ana

Zamay, Tatiana ^{[1
,2
]}

Kichkailo, Anna ^{[1
,2
]}

机构：

[1] Krasnoyarsk State Med Univ, Krasnoyarsk 660022, Russia

[2] Russian Acad Sci, Fed Res Ctr, KSC Siberian Branch, Krasnoyarsk 660022, Russia

来源：

MOLECULES | 2017年 / 22卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

magnetic nanoparticles; aptamers; drug delivery; magnetodynamic therapy; magnetic hyperthermia; magnetophoresis; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; FE3O4; NANOPARTICLES; IN-VITRO; PHOTOTHERMAL THERAPY; IMPEDIMETRIC SENSOR; TRIGGERED-RELEASE; GOLD NANOSHELLS; CONTRAST AGENTS; GENE DELIVERY;

D O I：

10.3390/molecules22060975

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes. Properties, production and functionalization of magnetic nanoparticles and aptamers as ligands for targeted delivery are discussed herein. In recent years, magnetic nanoparticles have been widely used in diagnostic methods, such as scintigraphy, single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and Raman spectroscopy. Therapeutic purposes of magnetic nanoconstructions are also promising. They are used for effective drug delivery, magnetic mediated hypertermia, and megnetodynamic triggering of apoptosis. Thus, magnetic nanotheranostics opens a new venue for complex differential diagnostics, and therapy of metastatic cancer.

引用

页数：19

共 120 条

[61] Magnetic nanoparticles:: Synthesis, protection, functionalization, and application [J].

Lu, An-Hui ;

Salabas, E. L. ;

Schueth, Ferdi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (08) :1222-1244

[62] Release of Photoactivatable Drugs from Plasmonic Nanoparticles for Targeted Cancer Therapy [J].

Luo, Yun-Ling ;

Shiao, Yi-Syun ;

Huang, Yu-Fen .

ACS NANO, 2011, 5 (10) :7796-7804

[63] Cell toxicity of superparamagnetic iron oxide nanoparticles [J].

Mahmoudi, M. ;

Simchi, A. ;

Milani, A. S. ;

Stroeve, P. .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2009, 336 (02) :510-518

[64] Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell "Vision" versus Physicochemical Properties of Nanoparticles [J].

Mahmoudi, Morteza ;

Laurent, Sophie ;

Shokrgozar, Mohammad A. ;

Hosseinkhani, Mohsen .

ACS NANO, 2011, 5 (09) :7263-7276

[65] Targeted nanoagents for the detection of cancers [J].

McCarthy, Jason R. ;

Bhaumik, Jayeeta ;

Karver, Mark R. ;

Erdem, S. Sibel ;

Weissleder, Ralph .

MOLECULAR ONCOLOGY, 2010, 4 (06) :511-528

[66] Doxorubicin-loaded magnetic gold nanoshells for a combination therapy of hyperthermia and drug delivery [J].

Mohammad, Faruq ;

Yusof, Nor Azah .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2014, 434 :89-97

[67] Microbial preparation of metal-substituted magnetite nanoparticles [J].

Moon, Ji-Won ;

Roh, Yul ;

Lauf, Robert J. ;

Vali, Hojatollah ;

Yeary, Lucas W. ;

Phelps, Tommy J. .

JOURNAL OF MICROBIOLOGICAL METHODS, 2007, 70 (01) :150-158

[68] Large-scale production of magnetic nanoparticles using bacterial fermentation [J].

Moon, Ji-Won ;

Rawn, Claudia J. ;

Rondinone, Adam J. ;

Love, Lonnie J. ;

Roh, Yul ;

Everett, S. Michelle ;

Lauf, Robert J. ;

Phelps, Tommy J. .

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2010, 37 (10) :1023-1031

[69] Inorganic Nanoparticles for MRI Contrast Agents [J].

Na, Hyon Bin ;

Song, In Chan ;

Hyeon, Taeghwan .

ADVANCED MATERIALS, 2009, 21 (21) :2133-2148

[70]

Nandwana Vikas, 2015, Cancer Treat Res, V166, P51, DOI 10.1007/978-3-319-16555-4_3

← 2 3 4 5 6 7 8 9 10 11 →