Targeted Magnetic Nanotheranostics of Cancer

被引：37

作者：

Belyanina, Irina ^{[1
]}

Kolovskaya, Olga ^{[1
,2
]}

Zamay, Sergey ^{[2
]}

Gargaun, Ana

Zamay, Tatiana ^{[1
,2
]}

Kichkailo, Anna ^{[1
,2
]}

机构：

[1] Krasnoyarsk State Med Univ, Krasnoyarsk 660022, Russia

[2] Russian Acad Sci, Fed Res Ctr, KSC Siberian Branch, Krasnoyarsk 660022, Russia

来源：

MOLECULES | 2017年 / 22卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

magnetic nanoparticles; aptamers; drug delivery; magnetodynamic therapy; magnetic hyperthermia; magnetophoresis; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; FE3O4; NANOPARTICLES; IN-VITRO; PHOTOTHERMAL THERAPY; IMPEDIMETRIC SENSOR; TRIGGERED-RELEASE; GOLD NANOSHELLS; CONTRAST AGENTS; GENE DELIVERY;

D O I：

10.3390/molecules22060975

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes. Properties, production and functionalization of magnetic nanoparticles and aptamers as ligands for targeted delivery are discussed herein. In recent years, magnetic nanoparticles have been widely used in diagnostic methods, such as scintigraphy, single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and Raman spectroscopy. Therapeutic purposes of magnetic nanoconstructions are also promising. They are used for effective drug delivery, magnetic mediated hypertermia, and megnetodynamic triggering of apoptosis. Thus, magnetic nanotheranostics opens a new venue for complex differential diagnostics, and therapy of metastatic cancer.

引用

页数：19

共 120 条

[1] Magnetic single-walled carbon nanotubes as efficient drug delivery nanocarriers in breast cancer murine model: noninvasive monitoring using diffusion-weighted magnetic resonance imaging as sensitive imaging biomarker [J].

Al Faraj, Achraf ;

Shaik, Abjal Pasha ;

Shaik, Asma Sultana .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 10 :157-168

[2]

Aleksandrova GP, 2004, PHYS MESOMECH, V7, P139

[3] Targeting cancer cells: magnetic nanoparticles as drug carriers [J].

Alexiou, Christoph ;

Schmid, Roswitha J. ;

Jurgons, Roland ;

Kremer, Marcus ;

Wanner, Gerhard ;

Bergemann, Christian ;

Huenges, Ernst ;

Nawroth, Thomas ;

Arnold, Wolfgang ;

Parak, Fritz G. .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2006, 35 (05) :446-450

[4] Drug targeting and tumor heterogeneity [J].

Bae, You Han .

JOURNAL OF CONTROLLED RELEASE, 2009, 133 (01) :2-3

[5] In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field [J].

Belyanina, Irina V. ;

Zamay, Tatiana N. ;

Zamay, Galina S. ;

Zamay, Sergey S. ;

Kolovskaya, Olga S. ;

Ivanchenko, Tatiana I. ;

Denisenko, Valery V. ;

Kirichenko, Andrey K. ;

Glazyrin, Yury E. ;

Garanzha, Irina V. ;

Grigorieva, Valentina V. ;

Shabanov, Alexandr V. ;

Veprintsev, Dmitry V. ;

Sokolov, Alexey E. ;

Sadovskii, Vladimir M. ;

Gargaun, Ana ;

Berezovski, Maxim V. ;

Kichkailo, Anna S. .

THERANOSTICS, 2017, 7 (13) :3326-3337

[6] Gold Nano-Popcorn Attached SWCNT Hybrid Nanomaterial for Targeted Diagnosis and Photothermal Therapy of Human Breast Cancer Cells [J].

Beqa, Lule ;

Fan, Zhen ;

Singh, Anant Kumar ;

Senapati, Dulal ;

Ray, Paresh Chandra .

ACS APPLIED MATERIALS & INTERFACES, 2011, 3 (09) :3316-3324

[7] In-situ formation of Fe3O4 nanoparticles within the thermo sensitive hairy hybrid particles [J].

Bi, Shuxian ;

Wei, Xiangyu ;

Li, Na ;

Lei, Zhongli .

MATERIALS LETTERS, 2008, 62 (17-18) :2963-2966

[8] Superparamagnetic agents in magnetic resonance imaging: Physicochemical characteristics and clinical applications - A review [J].

Bonnemain, B .

JOURNAL OF DRUG TARGETING, 1998, 6 (03) :167-174

[9] Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermally-Sensitive Polymers for Triggered Drug Release [J].

Brazel, Christopher S. .

PHARMACEUTICAL RESEARCH, 2009, 26 (03) :644-656

[10] Emerging Technologies of Polymeric Nanoparticles in Cancer Drug Delivery [J].

Brewer, Erik ;

Coleman, Jason ;

Lowman, Anthony .

JOURNAL OF NANOMATERIALS, 2011, 2011

← 1 2 3 4 5 6 7 8 9 10 →