Cortisol-induced impairments of working memory require acute sympathetic activation

被引:208
作者
Elzinga, BM [1 ]
Roelofs, K [1 ]
机构
[1] Leiden Univ, Sect Clin & Hlth Psychol, NL-2300 RB Leiden, Netherlands
关键词
D O I
10.1037/0735-7044.119.1.98
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The present study assessed whether the effects of cortisol on working memory depend on the level of adrenergic activity (as measured by sympathetic activation) during memory performance. After exposure to a psychosocial stress task, participants were divided into cortisol responders and nonresponders. Cortisol responders showed working memory impairments during the psychosocial stress phase, when cortisol and adrenergic activity were enhanced, whereas nonresponders did not. During recovery, however, when cortisol levels were elevated but adrenergic activity was normalized, working memory of responders did not differ from that of nonresponders. Among several stress measures, cortisol was the only significant predictor for working memory performance during stress. These findings suggest that adrenergic activation is essential for the impairing effects of stress-induced cortisol on working memory.
引用
收藏
页码:98 / 103
页数:6
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共 41 条
[1]   Catecholamine modulation of prefrontal cortical cognitive function [J].
Arnsten, AFT .
TRENDS IN COGNITIVE SCIENCES, 1998, 2 (11) :436-447
[2]   Noise stress impairs prefrontal cortical cognitive function in monkeys - Evidence for a hyperdopaminergic mechanism [J].
Arnsten, AFT ;
Goldman-Rakic, PS .
ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (04) :362-368
[3]   The fractionation of working memory [J].
Baddeley, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13468-13472
[4]   Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats [J].
Birnbaum, SG ;
Podell, DM ;
Arnsten, AFT .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2000, 67 (03) :397-403
[5]   A parametric study of prefrontal cortex involvement in human working memory [J].
Braver, TS ;
Cohen, JD ;
Nystrom, LE ;
Jonides, J ;
Smith, EE ;
Noll, DC .
NEUROIMAGE, 1997, 5 (01) :49-62
[6]   Enhanced memory for emotional material following stress-level cortisol treatment in humans [J].
Buchanan, TW ;
Lovallo, WR .
PSYCHONEUROENDOCRINOLOGY, 2001, 26 (03) :307-317
[7]   Enhanced human memory consolidation with post-learning stress: Interaction with the degree of arousal at encoding [J].
Cahill, L ;
Gorski, L ;
Le, K .
LEARNING & MEMORY, 2003, 10 (04) :270-274
[8]   Stress and cognition:: are corticosteroids good or bad guys? [J].
de Kloet, ER ;
Oitzl, MS ;
Joëls, M .
TRENDS IN NEUROSCIENCES, 1999, 22 (10) :422-426
[9]   Acute cortisone administration impairs retrieval of long-term declarative memory in humans [J].
de Quervain, DJF ;
Roozendaal, B ;
Nitsch, RM ;
McGaugh, JL ;
Hock, C .
NATURE NEUROSCIENCE, 2000, 3 (04) :313-314
[10]   Frontal lobes and human memory - Insights from functional neuroimaging [J].
Fletcher, PC ;
Henson, RNA .
BRAIN, 2001, 124 :849-881