Effect of cellulose nanocrystals on xylan/chitosan/nanoβ-TCP composite matrix for bone tissue engineering

被引：9
作者：
Ali, Asif [1 ]
Hasan, Abshar [2 ]
Negi, Yuvraj Singh [1 ]
机构：
[1] Indian Inst Technol Roorkee, Dept Polymer & Proc Engn, Saharanpur Campus, Saharanpur, Uttar Pradesh, India
[2] Univ Nottingham, Biodiscovery Inst, Sch Pharm, Nottingham NG7 2RD, England
来源：
CELLULOSE | 2022年 / 29卷 / 10期
关键词：
Xylan; Chitosan; beta-TCP; Cellulose nanocrystals; Bone tissue engineering; MAILLARD REACTION-PRODUCTS; NANOCOMPOSITE FILMS; CHITOSAN; XYLAN; SCAFFOLD; NANOWHISKERS; FABRICATION;
D O I：
10.1007/s10570-022-04607-5
中图分类号：
TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];
学科分类号：
0805 ; 080502 ; 0822 ;
摘要：
The current work intends to explore the effect of cellulose nanocrystals on the properties of xylan/chitosan/beta-tricalcium phosphate matrix for its application as bone tissue construct. The composite scaffold samples were synthesized using freeze drying process and characterized using Fourier-transform infrared spectrophotometry, X-Ray diffractometry, thermogravimetric analysis, and field emission scanning electron microscopy for their physicochemical properties. Microstructural analysis revealed alteration in pore size on tuning filler concentration from 1 to 10% with the highest pore size observed in composite with 5% CNC content. Addition of 1% CNC to the matrix significantly enhanced the compressive modulus and crystalline content of the material. Samples with 5% CNC content exhibited the highest thermal stability. All the composites with beta-TCP content demonstrated increased cell viability, alkaline phosphatase activity and mineralization tendency.
引用
收藏
页码：5689 / 5709
页数：21
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