Patients with dystrophinopathy show evidence of increased oxidative stress

被引：92

作者：

Rodriguez, MC

Tarnopolsky, MA

机构：

[1] McMaster Univ, Ctr Med, Neuromusc Dis Unit, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Dept Kinesiol, Hamilton, ON L8N 3Z5, Canada

[3] McMaster Univ, Dept Med Neurol & Rehab, Hamilton, ON L8N 3Z5, Canada

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2003年 / 34卷 / 09期

关键词：

muscular dystrophy; free radicals; DNA damage; 8-hydroxy-2 '-deoxyguanosine;

D O I：

10.1016/S0891-5849(03)00141-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Duchenne muscular dystrophy (DMD) is associated with an increase in oxidative stress. We measured 24 h 8-hydroxy-2'-deoxyguanosine (8-OHdG) excretion in 24 patients with MD (DMD + Becker's MD), 23 with myotonic dystrophy, and 34 healthy controls. The 8-OHdG/creatinine ratio was higher in patients with dystrophinopathy (up arrow 48%, p < .01) but not myotonic dystrophy, as compared to healthy controls. These results indicate that 8-OHdG excretion can be used as a marker of oxidative stress in clinical trials with dystrophinopathy. (C) 2003 Elsevier Inc.

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页码：1217 / 1220

页数：4

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