Generation of functional hemangioblasts from human embryonic stem cells

被引:144
作者
Lu, Shi-Jiang
Feng, Qiang
Caballero, Sergio
Chen, Yu
Moore, Malcolm A. S.
Grant, Maria B.
Lanza, Robert [1 ]
机构
[1] Adv Cell Technol, Worcester, MA 01605 USA
[2] Univ Florida, Program Stem Cell Biol, Gainesville, FL 32610 USA
[3] Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA
[4] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA
关键词
D O I
10.1038/nmeth1041
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages. Here we describe an efficient and reproducible method for generating large numbers of these bipotential progenitors-known as hemangioblasts-from human embryonic stem (hES) cells using an in vitro differentiation system. Blast cells expressed gene signatures characteristic of hemangioblasts, and could be expanded, cryopreserved and differentiated into multiple hematopoietic lineages as well as into endothelial cells. When we injected these cells into rats with diabetes or into mice with ischemia-reperfusion injury of the retina, they localized to the site of injury in the damaged vasculature and appeared to participate in repair. Injection of the cells also reduced the mortality rate after myocardial infarction and restored blood flow in hind limb ischemia in mouse models. Our data suggest that hES-derived blast cells (hES-BCs) could be important in vascular repair.
引用
收藏
页码:501 / 509
页数:9
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