The Effect of Statins on Perioperative Events in Patients Undergoing Vascular Surgery

被引:3
作者
Winkel, T. A. [1 ]
Schouten, O. [1 ,2 ]
Voute, M. T. [1 ]
Hoeks, S. E. [1 ]
Welten, G. M. [1 ]
Bax, J. J. [3 ]
Verhagen, H. J. M. [1 ]
Poldermans, D. [1 ]
机构
[1] Erasmus MC, Dept Vasc Surg, NL-3015 CE Rotterdam, Netherlands
[2] Reinier de Graaf Hosp, Dept Surg, Delft, Netherlands
[3] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands
关键词
Perioperative cardiovascular events; statins; vascular surgery; MORTALITY; SAFETY; ASSOCIATION; REDUCTION; THERAPY;
D O I
10.1080/00015458.2010.11680560
中图分类号
R61 [外科手术学];
学科分类号
摘要
Despite recent advancements in perioperative care and guideline recommendations, patients undergoing vascular surgery remain at risk for perioperative cardiovascular complications. In this review, the results are summarized of the most recent studies on the effectiveness and safety of perioperative statin use for the prevention of these perioperative cardiovascular complications. Perioperative statin therapy was associated with an improvement in postoperative cardiovascular outcome and a reduction in serum lipid levels and levels of inflammation markers.
引用
收藏
页码:28 / 31
页数:4
相关论文
共 21 条
[1]   Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes - New evidence for direct antiinflammatory effects of statins [J].
Arnaud, C ;
Burger, F ;
Steffens, S ;
Veillard, NR ;
Nguyen, TH ;
Trono, D ;
Mach, F .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (06) :1231-1236
[2]   Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins [J].
Baigent, C ;
Keech, A ;
Kearney, PM ;
Blackwell, L ;
Buck, G ;
Pollicino, C ;
Kirby, A ;
Sourjina, T ;
Peto, R ;
Collins, R ;
Simes, J .
LANCET, 2005, 366 (9493) :1267-1278
[3]   Histological analysis of coronary artery lesions in fatal postoperative myocardial infarction [J].
Cohen, MC ;
Aretz, TH .
CARDIOVASCULAR PATHOLOGY, 1999, 8 (03) :133-139
[4]   Pathology of fatal perioperative myocardial infarction: Implications regarding pathophysiology and prevention [J].
Dawood, MM ;
Gutpa, DK ;
Southern, J ;
Walia, A ;
Atkinson, JB ;
Eagle, KA .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 1996, 57 (01) :37-44
[5]   Reduction in cardiovascular events after vascular surgery with atorvastatin: A randomized trial [J].
Durazzo, AES ;
Machado, FS ;
Ikeoka, DT ;
De Bernoche, C ;
Monachini, MC ;
Puech-Leao, P ;
Caramelli, B .
JOURNAL OF VASCULAR SURGERY, 2004, 39 (05) :967-975
[6]   Withdrawal of statins increases event rates in patients with acute coronary syndromes [J].
Heeschen, C ;
Hamm, CW ;
Laufs, U ;
Snapinn, S ;
Böhm, M ;
White, HD .
CIRCULATION, 2002, 105 (12) :1446-1452
[7]   Improved postoperative outcomes associated with preoperative statin therapy [J].
Hindler, Katja ;
Shaw, Andrew D. ;
Samuels, Joshua ;
Fulton, Stephanie ;
Collard, Charles D. ;
Riedel, Bernhard .
ANESTHESIOLOGY, 2006, 105 (06) :1260-1272
[8]   Association between long-term statin use and mortality after successful abdominal aortic aneurysm surgery [J].
Kertai, MD ;
Boersma, E ;
Westerhout, CM ;
van Domburg, R ;
Klein, J ;
Bax, JJ ;
van Urk, H ;
Poldermans, D .
AMERICAN JOURNAL OF MEDICINE, 2004, 116 (02) :96-103
[9]   Association of cardiac troponin, CK-MB, and postoperative myocardial ischemia with long-term survival after major vascular surgery [J].
Landesberg, G ;
Shatz, V ;
Akopnik, I ;
Wolf, YG ;
Mayer, M ;
Berlatzky, Y ;
Weissman, C ;
Mosseri, M .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (09) :1547-1554
[10]   The impact of postoperative discontinuation or continuation of chronic statin therapy on cardiac outcome after major vascular surgery [J].
Le Manach, Yannick ;
Godet, Gilles ;
Coriat, Pierre ;
Martinon, Claire ;
Bertrand, Michele ;
Fleron, Marie-Helene ;
Riou, Bruno .
ANESTHESIA AND ANALGESIA, 2007, 104 (06) :1326-1333