AAV Mediated Expression of Mouse IL-12 Shows Potent Anti-Tumor Activity and Immune Response Alone and in Combination with Anti-PD1 in Syngeneic Murine Tumor Models

被引:0
|
作者
Sutton, David [1 ]
Prentiss, Pilar [1 ]
Furmanski, Brian [1 ]
机构
[1] Kriya Therapeut, Translat Dev, Redwood City, CA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
337
引用
收藏
页码:161 / 161
页数:1
相关论文
共 50 条
  • [1] AAV-mediated expression of mouse IL-12 shows potent anti-tumor activity through innate immunological activation in syngeneic murine cancer models
    Fellner, D.
    Prentiss, P.
    Liu, J.
    Stone, M.
    Stone, M.
    Roeloffs, R.
    Furmanski, B.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A186 - A186
  • [2] Cabozantinib in combination with anti-PD1 immune checkpoint inhibitor in syngeneic tumor mouse models
    Rolland, S.
    Klinz, S. G.
    Meyer-Losic, F.
    Nahkle, J.
    Delille, R.
    de Boisferon, M. Hillairet
    ANNALS OF ONCOLOGY, 2018, 29
  • [3] Combination of recombinant murine IL-12 and anti-PD-1 induced synergistic anti-tumor response.
    Tsou, Peiyi
    Lin, Wan-Ying
    Lee, Meng-Na
    Chen, San-Chi
    CANCER RESEARCH, 2022, 82 (12)
  • [4] Fungal Depletion Bolsters Anti-Tumor Immune Response Elicited by Anti-PD1 Alone and in Combination with Radiation Therapy
    Stevens, S.
    Jang, J. K.
    Kershaw, K.
    Viramontes, J.
    Dar, T. B.
    Nguyen, A. T.
    Henson, R.
    Guarnerio, J.
    Underhill, D.
    Shiao, S. L.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2023, 117 (02): : S166 - S166
  • [5] Preclinical assessment of anti-tumor activity and immune response in syngeneic tumor models
    Franklin, M.
    Thayer, M.
    Draper, D.
    Saims, D.
    Wise, S.
    EUROPEAN JOURNAL OF CANCER, 2016, 69 : S97 - S97
  • [6] Anti-tumor activity of PEGylated human IL-10 (AM0010) in renal cancer alone and in combination with anti-PD1
    Naing, A.
    Papadopoulos, K. P.
    Autio, K. A.
    Ott, P. A.
    Patel, M. R.
    Wong, D. J.
    Falchook, G.
    Pant, S.
    Whiteside, M.
    Rasco, D.
    Patnaik, A.
    Bendell, J. C.
    Bauer, T. M.
    Colen, R. R.
    Hong, D.
    Van Vlasselaer, P.
    Brown, G. L.
    Oft, M.
    Tannir, N.
    Infante, J. R.
    ANNALS OF ONCOLOGY, 2016, 27
  • [7] Anti-tumor activity of PEGylated human IL-10 (AM0010) in renal cancer alone and in combination with anti-PD1
    Naing, Aung
    Pant, Shubham
    Infante, Jeffrey
    Papadopoulos, Kyriakos
    Autio, Karen
    Wong, Deborah
    Ott, Patrick
    Falchook, Gerald
    Patel, Manish
    Whiteside, Melinda
    Colen, Rivka
    Bendell, Johanna
    Bauer, Todd
    Janku, Filip
    Javle, Milind
    Tannir, Nixar
    Oft, Martin
    Chan, Ivan
    Rasco, Drew
    Hong, David
    Patnaik, Amita
    Moore, Kathen
    Korn, Michael
    Van-Vlasselaer, Peter
    Brown, Gail
    BJU INTERNATIONAL, 2016, 118 : 25 - 25
  • [8] A half-life extended, tumor-activated IL-12 increased the infiltration of effector immune cells into the tumor microenvironment and demonstrated anti-tumor activity in syngeneic mouse models
    Malkova, Natalia
    Patel, Ekta
    Vu, Sallyann
    Fantini, Damiano
    O'Donnell, Rebekah
    Fanny, Manoussa
    Greene, Justin
    Guzman, Wilson
    Crowe, David
    Hsiao, Stephanie
    Johnson, Parker
    McLaughlin, Megan
    Yerov, Oleg
    Jenkins, Kurt
    Halpin-Veszeleiova, Katarina
    Madala, Hanumantha Rao
    O'Toole, Caitlin
    Taylor, Jake
    Pederzoli-Ribeil, Magali
    Nicholson, Benjamin
    Bialucha, Carl Uli
    O'Neil, Jennifer E.
    CANCER RESEARCH, 2023, 83 (07)
  • [9] Cabozantinib in combination with anti-PD1 immune checkpoint inhibitor in syngeneic tumour mouse models
    Sparks, R.
    Rolland, S.
    Klinz, S.
    Meyer-Losic, F.
    Nakhle, J.
    Delille, R.
    de Boisferonc, M. Hillairet
    ANNALS OF ONCOLOGY, 2019, 30
  • [10] Inhibition of arginase in combination with radiation therapy shows increased immune-activation and anti-tumor activity in syngeneic tumor models.
    Schuller, Alwin
    Doshi, Aatman
    Cantin, Susan
    Griffin, Matt
    San Martin, Maryann
    Proia, Theresa
    Reimer, Corinne
    Mlynarski, Scott
    Finlay, Ray
    Shao, Wenlin
    CANCER RESEARCH, 2021, 81 (13)