The Future of Aminoglycosides: The End or Renaissance?

被引：150

作者：

Houghton, Jacob L. ^{[1
,3
]}

Green, Keith D. ^{[3
]}

Chen, Wenjing ^{[2
,3
]}

Garneau-Tsodikova, Sylvie ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Coll Pharm, Dept Med Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Chem Biol Doctoral Program, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 07期

关键词：

aminoglycosides; antibiotics; antiviral agents; chemoenzymatic synthesis; drug resistance; genetic diseases; GCN5-RELATED N-ACETYLTRANSFERASE; ANTIBIOTIC-RESISTANCE ENZYME; DIMERIZATION INITIATION SITE; 30S RIBOSOMAL-SUBUNIT; CRYSTAL-STRUCTURE; A-SITE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; SUBSTRATE-SPECIFICITY; MODIFYING ENZYME;

D O I：

10.1002/cbic.200900779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front-line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV-1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.

引用

页码：880 / 902

页数：23

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