The Future of Aminoglycosides: The End or Renaissance?

被引：150
作者：
Houghton, Jacob L. [1 ,3 ]
Green, Keith D. [3 ]
Chen, Wenjing [2 ,3 ]
Garneau-Tsodikova, Sylvie [1 ,2 ,3 ]
机构：
[1] Univ Michigan, Coll Pharm, Dept Med Chem, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Chem Biol Doctoral Program, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
来源：
CHEMBIOCHEM | 2010年 / 11卷 / 07期
关键词：
aminoglycosides; antibiotics; antiviral agents; chemoenzymatic synthesis; drug resistance; genetic diseases; GCN5-RELATED N-ACETYLTRANSFERASE; ANTIBIOTIC-RESISTANCE ENZYME; DIMERIZATION INITIATION SITE; 30S RIBOSOMAL-SUBUNIT; CRYSTAL-STRUCTURE; A-SITE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; SUBSTRATE-SPECIFICITY; MODIFYING ENZYME;
D O I：
10.1002/cbic.200900779
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front-line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV-1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.
引用
收藏
页码：880 / 902
页数：23
相关论文
共 167 条
[1]   Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides [J].
Aires, JR ;
Köhler, T ;
Nikaido, H ;
Plésiat, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (11) :2624-2628
[2]   Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line [J].
Bedwell, DM ;
Kaenjak, A ;
Benos, DJ ;
Bebok, Z ;
Bubien, JK ;
Hong, J ;
Tousson, A ;
Clancy, JP ;
Sorscher, EJ .
NATURE MEDICINE, 1997, 3 (11) :1280-1284
[3]   Cleavage of RNA oligonucleotides by aminoglycosides [J].
Belousoff, Matthew J. ;
Graham, Bim ;
Spiccia, Leone ;
Tor, Yitzhak .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2009, 7 (01) :30-33
[4]   Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion [J].
Bernacchi, Serena ;
Freisz, Severine ;
Maechling, Clarisse ;
Spiess, Bernard ;
Marquet, Roland ;
Dumas, Philippe ;
Ennifar, Eric .
NUCLEIC ACIDS RESEARCH, 2007, 35 (21) :7128-7139
[5]   Genetics of aminoglycocide-induced and prelingual non-syndromic mitochondrial hearing impairment: A review [J].
Bindu, L. Hema ;
Reddy, P. P. .
INTERNATIONAL JOURNAL OF AUDIOLOGY, 2008, 47 (11) :702-707
[6]   A tale of two targets: Differential RNA selectivity of nucleobase-aminoglycoside conjugates [J].
Blount, Kenneth F. ;
Tor, Yitzhak .
CHEMBIOCHEM, 2006, 7 (10) :1612-1621
[7]   Conformational constraint as a means for understanding RNA-aminoglycoside specificity [J].
Blount, KF ;
Zhao, F ;
Hermann, T ;
Tor, Y .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (27) :9818-9829
[8]   Synthesis of a neamine dimer targeting the dimerization initiation site of HIV-1 RNA [J].
Bodlenner, Anne ;
Alix, Aurelien ;
Weibel, Jean-Marc ;
Pale, Patrick ;
Ennifar, Eric ;
Paillart, Jean-Christophe ;
Walter, Philippe ;
Marquet, Roland ;
Dumas, Philippe .
ORGANIC LETTERS, 2007, 9 (22) :4415-4418
[9]   The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6′-aminoglycoside phosphotransferase-2" -: The role of Asp-99 as an active site base important for acetyl transfer [J].
Boehr, DD ;
Jenkins, SI ;
Wright, GD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (15) :12873-12880
[10]   Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step [J].
Borkow, G ;
Vijayabaskar, V ;
Lara, HH ;
Kalinkovich, A ;
Lapidot, A .
ANTIVIRAL RESEARCH, 2003, 60 (03) :181-192
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