In vivo endoscopic multi-beam optical coherence tomography

被引：43
作者：
Standish, Beau A. [1 ]
Lee, Kenneth K. C. [2 ]
Mariampillai, Adrian [1 ]
Munce, Nigel R. [1 ]
Leung, Michael K. K. [1 ]
Yang, Victor X. D. [2 ,3 ,4 ]
Vitkin, I. Alex [1 ,2 ,5 ]
机构：
[1] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
[2] Univ Hlth Network, Ontario Canc Inst, Toronto, ON, Canada
[3] Ryerson Univ, Dept Elect & Comp Engn, Toronto, ON, Canada
[4] Sunnybrook Hlth Sci Ctr, Dept Imaging Res, Toronto, ON M4N 3M5, Canada
[5] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2010年 / 55卷 / 03期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1088/0031-9155/55/3/004
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of < 10 mu m full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation between the structural multi-beam OCT images and H&E histology was achieved, demonstrating the feasibility of this high-resolution system and its potential for in vivo human endoscopic imaging.
引用
收藏
页码：615 / 622
页数：8
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