Oxadiazole: A highly versatile scaffold in drug discovery

被引：42

作者：

Desai, Nisheeth ^{[1
]}

Monapara, Jahnvi ^{[1
]}

Jethawa, Aratiba ^{[1
]}

Khedkar, Vijay ^{[2
]}

Shingate, Bapurao ^{[3
]}

机构：

[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem, Div Med Chem, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India

[2] Vishwakarma Univ, Sch Pharm, Pune, Maharashtra, India

[3] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad, Maharashtra, India

来源：

ARCHIV DER PHARMAZIE | 2022年 / 355卷 / 09期

关键词：

1; 3; 4-oxadiazole; anticancer; anti-HIV; antitubercular; molecular docking; 1,3,4-OXADIAZOLE ANALOGS SYNTHESIS; MOLECULAR-PROPERTIES PREDICTION; BIOLOGICAL EVALUATION; ANTIMYCOBACTERIAL ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; CLUBBED 1,3,4-OXADIAZOLES; ANTIMICROBIAL ACTIVITY; ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; CYTOTOXIC AGENTS;

D O I：

10.1002/ardp.202200123

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a pharmacologically important heterocycle, oxadiazole paved the way to combat the problem associated with the confluence of many commercially available drugs with different pharmacological profiles. The present review focuses on the potential applications of five-membered heterocyclic oxadiazole derivatives, especially 1,2,4-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole, as therapeutic agents. Designing new hybrid molecules containing the oxadiazole moiety is a better solution for the development of new drug molecules. The designed molecules may accumulate a biological profile better than those of the drugs currently available on the market. The present review will guide the way for researchers in the field of medicinal chemistry to design new biologically active molecules based on the oxadiazole nucleus. Antitubercular, antimalarial, anti-inflammatory, anti-HIV, antibacterial, and anticancer activities of various oxadiazoles have been reviewed extensively here.

引用

页数：44

共 159 条

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