Leptin-induced decrease in food intake in chickens

被引：130

作者：

Denbow, DM ^{[1
]}

Meade, S

Robertson, A

McMurtry, JP

Richards, M

Ashwell, C

机构：

[1] Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA

[2] USDA ARS, Growth Biol Lab, Beltsville, MD 20705 USA

来源：

PHYSIOLOGY & BEHAVIOR | 2000年 / 69卷 / 03期

关键词：

leptin; food intake; water intake; chickens;

D O I：

10.1016/S0031-9384(99)00258-9

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The effect of intracerebroventricular (i.c.v.) injection of leptin was investigated using broiler and Single Comb White Leghorn (SCWL)-type chickens. These represent relatively fast- and slow-growing birds, respectively. The i.c.v. injection of leptin decreased food intake in both broilers and Leghorns in a dose-dependent manner. The most efficacious dose appeared to be 10 mu g in both types of chickens. Water intake was generally not affected by leptin, indicating that this effect was not due to general malaise. It appears that leptin can act within the central nervous sytstem of birds to decrease food intake. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：359 / 362

页数：4

共 27 条

[1] CLEARANCE OF MOLECULES FROM CEREBROSPINAL-FLUID IN CHICKENS [J].

ANDERSON, DK ;

HEISEY, SR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1972, 222 (03) :645-&

[2] Hormonal regulation of leptin expression in broiler chickens [J].

Ashwell, CM ;

Czerwinski, SM ;

Brocht, DM ;

McMurtry, JP .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1999, 276 (01) :R226-R232

[3] Leptin enters the brain by a saturable system independent of insulin [J].

Banks, WA ;

Kastin, AJ ;

Huang, WT ;

Jaspan, JB ;

Maness, LM .

PEPTIDES, 1996, 17 (02) :305-311

[4] Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine [J].

Barb, CR ;

Yan, X ;

Azain, MJ ;

Kraeling, RR ;

Rampacek, GB ;

Ramsay, TG .

DOMESTIC ANIMAL ENDOCRINOLOGY, 1998, 15 (01) :77-86

[5]

BONAMPONSEM K, 1999, AVIAN PATHOL, V28, P379

[6] Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken [J].

Bungo, T ;

Shimojo, M ;

Masuda, Y ;

Tachibanab, T ;

Tanaka, SJ ;

Sugahara, K ;

Furuse, M .

BRAIN RESEARCH, 1999, 817 (1-2) :196-198

[7] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].

CAMPFIELD, LA ;

SMITH, FJ ;

GUISEZ, Y ;

DEVOS, R ;

BURN, P .

SCIENCE, 1995, 269 (5223) :546-549

[8] Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice [J].

Chen, H ;

Charlat, O ;

Tartaglia, LA ;

Woolf, EA ;

Weng, X ;

Ellis, SJ ;

Lakey, ND ;

Culpepper, J ;

Moore, KJ ;

Breitbart, RE ;

Duyk, GM ;

Tepper, RI ;

Morgenstern, JP .

CELL, 1996, 84 (03) :491-495

[9] The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically Obese falfa rats - Reduced sensitivity compared with lean animals [J].

Cusin, I ;

RohnerJeanrenaud, F ;

StrickerKrongrad, A ;

Jeanrenaud, B .

DIABETES, 1996, 45 (10) :1446-1451

[10] IONOSTATIC CONTROL OF FOOD-INTAKE IN THE DOMESTIC-FOWL [J].

DENBOW, DM ;

VANKREY, HP .

POULTRY SCIENCE, 1987, 66 (07) :1229-1235

← 1 2 3 →