Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

被引：264
作者：
Wu, Luling [1 ,2 ]
Liu, Jihong [1 ,2 ]
Li, Ping [1 ]
Tang, Bo [1 ]
James, Tony D. [1 ,2 ,3 ]
机构：
[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ,Inst Biomed, Jinan 250014, Peoples R China
[2] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
来源：
CHEMICAL SOCIETY REVIEWS | 2021年 / 50卷 / 02期
基金：
中国国家自然科学基金; 英国工程与自然科学研究理事会;
关键词：
Photodynamic therapy - Fluorescence - Photons - Molecules - Energy transfer;
D O I：
10.1039/d0cs00861c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes. The advantages of TPEF-based probes include deep tissue penetration and minimal photo-damage. We discuss the underlying two-photon (TP) fluorophores including hemicyanine and design strategies such as Forster resonance energy transfer (FRET). Moreover, we emphasize applications for the detection or imaging of cations, anions, small neutral molecules, biomacromolecules, cellular microenvironments, subcellular localization and dual-responsive systems. Examples of photodynamic therapy (PDT) using TP irradiation are also illustrated.
引用
收藏
页码：702 / 734
页数：33
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