Dendronized mesoporous silica nanoparticles provide an internal endosomal escape mechanism for successful cytosolic drug release

被引：17
|
作者：
Weiss, Veronika [1 ,2 ]
Argyo, Christian [1 ,2 ]
Torrano, Adriano A. [1 ,2 ]
Strobel, Claudia [3 ]
Mackowiak, Stephan A. [1 ,2 ]
Schmidt, Alexandra [1 ,2 ]
Datz, Stefan [1 ,2 ]
Gatzenmeier, Tim [1 ,2 ]
Hilger, Ingrid [3 ]
Braeuchle, Christoph [1 ,2 ]
Bein, Thomas [1 ,2 ]
机构：
[1] Univ Munich LMU, Dept Phys Chem, Gerhard Ertl Bldg,Butenandtstr 5-13, D-81377 Munich, Germany
[2] Univ Munich LMU, Ctr NanoSci CeNS, Gerhard Ertl Bldg,Butenandtstr 5-13, D-81377 Munich, Germany
[3] Univ Jena, Jena Univ Hosp, Inst Diagnost & Intervent Radiol 1, Dept Expt Radiol, Erlanger Allee 101, D-07747 Jena, Germany
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2016年 / 227卷
关键词：
Mesoporous silica nanoparticles; PAMAM dendrimers; Endosomal escape; Drug nanocarriers; Specific drug release; GENE DELIVERY; PAMAM DENDRIMERS; SIRNA DELIVERY; CELLS; POLYMERS; POLYPLEXES; COLCHICINE; STABILITY; MOLECULES; PROPERTY;
D O I：
10.1016/j.micromeso.2016.03.017
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Mesoporous silica nanoparticles (MSNs) attract increasing interest in the field of gene and drug delivery due to their versatile features as a multifunctional drug delivery platform. Here, we describe poly(amidoamine) (PAMAM) dendron-functionalized MSNs that fulfill key prerequisites for a controllable intracellular drug release. In addition to high loading capacity, they offer 1) low cytotoxicity, showing no impact on the metabolism of endothelial cells, 2) specific cancer cell targeting due to receptor-mediated cell uptake, 3) a redox-driven cleavage of disulfide bridges allowing for stimuli-responsive cargo release, and most importantly, 4) a specific internal trigger based on the high buffering capacity of PAMAM dendrons to provide endosomal escape. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：242 / 251
页数：10
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