A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ

被引：281
作者：
Aggarwal, VK
de Vicente, J
Bonnert, RV
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 ITS, Avon, England
[2] AstraZeneca R&D Charnwood, Med Chem, Loughborough LE11 5RH, Leics, England
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 13期
关键词：
D O I：
10.1021/jo0268409
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles. Furthermore, the reaction of N-vinylimidazole and diazo compounds derived from aldehydes gave exclusively 3-substituted pyrazoles in a one-pot process.
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页码：5381 / 5383
页数：3
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