Manganese(I)-Catalyzed Enantioselective Hydrogenation of Ketones Using a Defined Chiral PNP Pincer Ligand

被引：185

作者：

Garbe, Marcel ^{[1
]}

Junge, Kathrin ^{[1
]}

Walker, Svenja ^{[1
]}

Wei, Zhihong ^{[1
]}

Jiao, Haijun ^{[1
]}

Spannenberg, Anke ^{[1
]}

Bachmann, Stephan ^{[2
]}

Scalone, Michelangelo ^{[2
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

[2] F Hoffmann La Roche Ltd, Proc Chem & Catalysis, CH-4070 Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 37期

关键词：

asymmetric hydrogenation; chiral alcohols; chiral pincer ligands; ketones; manganese; ASYMMETRIC TRANSFER HYDROGENATION; C BOND FORMATION; P-N-P'; IRON(II) COMPLEXES; CATALYTIC-HYDROGENATION; EFFICIENT; ALCOHOLS; AMINES; ALKYLATION; REDUCTION;

D O I：

10.1002/anie.201705471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new chiral manganese PNP pincer complex is described. The asymmetric hydrogenation of several prochiral ketones with molecular hydrogen in the presence of this complex proceeds under mild conditions (30-40 degrees C, 4 h, 30 bar H-2). Besides high catalytic activity for aromatic substrates, aliphatic ketones are hydrogenated with remarkable selectivity (e.r. up to 92:8). DFT calculations support an outer sphere hydrogenation mechanism as well as the experimentally determined stereochemistry.

引用

页码：11237 / 11241

页数：5

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