Clinical course and cost assessment of infants with a first episode of acute bronchiolitis presenting to the emergency department: Data from the GUERANDE clinical trial

被引：3

作者：

Butel, Thibault ^{[1
]}

Angoulvant, Francois ^{[2
]}

Filipovic-Pierucci, Antoine ^{[1
]}

Milcent, Karen ^{[4
,5
]}

Teglas, Jean-Paul ^{[5
]}

Bellettre, Xavier ^{[3
]}

Claudet, Isabelle ^{[6
]}

Gras-le Guen, Christele ^{[7
]}

de Pontual, Loic ^{[8
]}

Minodier, Philippe ^{[9
]}

Dubos, Francois ^{[10
]}

Brouard, Jacques ^{[11
]}

Soussan-Banini, Valerie ^{[12
]}

Degas-Bussiere, Vanessa ^{[13
]}

Gatin, Amelie ^{[14
]}

Schweitzer, Cyril ^{[14
]}

Epaud, Ralph ^{[15
]}

Ryckewaert, Amelie ^{[16
]}

Cros, Pierrick ^{[17
]}

Marot, Yves ^{[18
]}

Flahaut, Philippe ^{[19
]}

Saunier, Pascal ^{[20
]}

Babe, Philippe ^{[21
]}

Patteau, Geraldine ^{[2
]}

Delebarre, Mathilde ^{[10
]}

Titomanlio, Luigi ^{[3
]}

Vrignaud, Benedicte ^{[7
]}

Trieu, Thanh-Van ^{[8
]}

Tahir, Abdelilah ^{[22
]}

Regnard, Delphine ^{[23
]}

Micheau, Pascale ^{[6
]}

Charara, Oussama ^{[24
]}

Henry, Simon ^{[25
]}

Ploin, Dominique ^{[26
]}

Panjo, Henri ^{[5
]}

Vabret, Astrid ^{[11
]}

Bouyer, Jean ^{[5
]}

Durand-Zaleski, Isabelle ^{[1
]}

Gajdos, Vincent ^{[4
,5
]}

机构：

[1] AP HP, Clin Res Unit Hlth Econ, Paris, France

[2] Necker Enfants Malad Univ Hosp, AP HP, Dept Pediat Emergency, Paris, France

[3] Robert Debre Univ Hosp, AP HP, Dept Pediat Emergency, Paris, France

[4] Antoine Beclere Univ Hosp, AP HP, Dept Pediat Emergency, Clamart, France

[5] CESP Ctr Res Epidemiol & Populat Hlth, INSERM U1018, Villejuif, France

[6] Toulouse Univ Hosp, Dept Pediat Emergency, Toulouse, France

[7] Nantes Univ Hosp, Dept Pediat Emergency, Nantes, France

[8] Jean Verdier Univ Hosp, AP HP, Dept Pediat Emergency, Bondy, France

[9] Marseille Nord Univ Hosp, AP HM, Dept Pediat Emergency, Marseille, France

[10] Lille Univ Hosp, Dept Pediat Emergency, Lille, France

[11] Caen Univ Hosp, Dept Pediat Emergency, Caen, France

[12] Ambroise Pare Univ Hosp, AP HP, Dept Pediat Emergency, Boulogne, France

[13] Sud Francilien Hosp, Dept Pediat Emergency, Corbeil Essonnes, France

[14] Nancy Univ Hosp, Dept Pediat Emergency, Nancy, France

[15] Creteil Intercommunal Hosp, Dept Pediat Emergency, Creteil, France

[16] Rennes Univ Hosp, Dept Pediat Emergency, Rennes, France

[17] Brest Univ Hosp, Dept Pediat Emergency, Brest, France

[18] Tours Univ Hosp, Dept Pediat Emergency, Tours, France

[19] Rouen Univ Hosp, Dept Pediat Emergency, Rouen, France

[20] Fontainebleau Hosp, Dept Pediat Emergency, Fontainebleau, France

[21] Lenval Univ Hosp, Dept Pediat Emergency, Nice, France

[22] Limoges Univ Hosp, Dept Pediat Emergency, Limoges, France

[23] Bicetre Univ Hosp, AP HP, Dept Pediat Emergency, Le Kremlin Bicetre, France

[24] Andre Mignot Hosp, Dept Pediat Emergency, Le Chesnay, France

[25] Laenneck Hosp, Dept Pediat Emergency, Quimper, France

[26] Mother Child Univ Hosp, HCL, Dept Pediat Emergency, Bron, France

来源：

PEDIATRIC PULMONOLOGY | 2021年 / 56卷 / 12期

关键词：

asthma & early wheeze; bronchiolitis; economic evaluation; epidemiology; RESPIRATORY SYNCYTIAL VIRUS; NEBULIZED HYPERTONIC SALINE; LENGTH-OF-STAY; VIRAL BRONCHIOLITIS; INTENSIVE-CARE; BURDEN; HOSPITALIZATION; EPIDEMIOLOGY; MULTICENTER; INFECTION;

D O I：

10.1002/ppul.25621

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Introduction Bronchiolitis is the leading cause of hospitalization for infants but its economic burden is not well documented. Our objective was to describe the clinical evolution and to assess the 1-month cost of a first episode of acute bronchiolitis presenting to the emergency department (ED). Methods Our study was an epidemiologic analysis and a cost study of the cohort drawn from the clinical trial GUERANDE, conducted in 24 French pediatric EDs. Infants of 6 weeks to 12 months of age presenting at pediatric EDs with a first episode of bronchiolitis were eligible. The costs considered were collected from a societal viewpoint, according to the recommendations of the French National Health Authority. Results A total of 777 infants were included with a median age of 4 months. A total of 57% were hospitalized during the month following the first consultation in the ED, including 28 (3.6%) in an intensive care unit. The mean length of stay was 4.2 days (SD = 3.7). The average time to relief of all symptoms was 13 days (SD = 7). Average total cost per patient was euro1919 (95% confidence interval: 1756-2138) from a societal perspective, mostly due to hospitalization cost. The estimated annual cost of bronchiolitis in infants was evaluated to be between euro160 and euro273 million in France. Discussion Bronchiolitis represent a high cost for the health care system and broadly for society, with hospitalizations costs being the main cost driver. Thus significant investments should be made to develop innovative therapies, to reduce the number of hospitalizations and length of stay.

引用

页码：3802 / 3812

页数：11

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