A One-Pot, Multicomponent Synthesis of 5′-Amino-2,2′-dioxospiro[indoline-3,3′-pyrrole]-4′-carbonitriles

被引：13

作者：

Adib, Mehdi ^{[1
]}

Yasaei, Zahra ^{[1
]}

Mirzaei, Peiman ^{[2
]}

机构：

[1] Univ Tehran, Sch Chem, Coll Sci, POB 14155-6455, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

来源：

SYNLETT | 2016年 / 27卷 / 03期

关键词：

isatins; isocyanides; spiro compounds; lactams; multicomponent reactions; STRUCTURE-BASED DESIGN; SPIROTRYPROSTATIN-B; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; RHYNCHOPHYLLINE; CYCLOADDITION; ISORHYNCHOPHYLLINE; SPIROOXINDOLES; CONSTRUCTION; INHIBITOR;

D O I：

10.1055/s-0035-1560963

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot, multicomponent synthesis of 5-amino-2,2-dioxospiro[indoline-3,3-pyrrole]-4-carbonitriles is described. The Knoevenagel condensation reaction between isatin derivatives and malononitrile gave the corresponding cyclic arylmethylidenemalononitriles that, on treatment with isocyanides, afforded 2,2-dioxospiro-bis--lactams in good to excellent yields.

引用

收藏

页码：383 / 386

页数：4

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